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Determination of naltrexone dosage for narcotic agonist blockade in detoxified Asian addicts
(Détermination de la dose de naltrexone nécessaire au blocage des effets de l'héroïne chez des toxicomanes asiatiques)
Auteur(s) :
NAVARATNAM, V. ;
JAMALUDIN A. ;
RAMAN N. ;
MOHAMED M. ;
MANSOR S. M.
Année
1994
Langue(s) :
Anglais
ISBN :
0376-8716
Refs biblio. :
13
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
HEROINE
;
NALTREXONE
;
ANTAGONISTE
;
SEVRAGE
;
EFFICACITE
;
MESURES QUANTITATIVES
Note générale :
Drug and Alcohol Dependence , 1994, 34, 231-236
Résumé :
FRANÇAIS :
Sur des toxicomanes chinois, malais et indous ayant terminé leur sevrage, on teste trois doses de naltrexone et un placebo de l'héroïne. La naltrexone est efficace pour inhiber les effets phsyiologiques et psychologiques de l'héroïne durant une période de 48 h à 72 h. Il n'y a pas de variation de cette efficacité en fonction du groupe ethnique.
ENGLISH :
Thirty-eight, adult, male, detoxified, Malaysian opiate addicts participated in this double-blind clinical evaluation of naltrexone. Addicts from three ethnic groups : Chinese, Malays, and Indians received a weekly regimen of naltrexone (100 mg on Day 1 and 3 and 150 mg on Day 5). Subjects were randomly assigned to receive intravenous challenge with either 25 mg heroin or placebo 12, 24, 48, and 72 h after the third naltrexone dose. Physiological and subjective parameters were measured at each challenge interval. Results indicated that naltrexone was effective in blocking the physiological and psychological effects of heroin for at least 48 and 72 h, respectively, in detoxified Malaysian opiate addicts. The efficacy of naltrexone did not differ among the three ethnic groups evaluated in this study.
Sur des toxicomanes chinois, malais et indous ayant terminé leur sevrage, on teste trois doses de naltrexone et un placebo de l'héroïne. La naltrexone est efficace pour inhiber les effets phsyiologiques et psychologiques de l'héroïne durant une période de 48 h à 72 h. Il n'y a pas de variation de cette efficacité en fonction du groupe ethnique.
ENGLISH :
Thirty-eight, adult, male, detoxified, Malaysian opiate addicts participated in this double-blind clinical evaluation of naltrexone. Addicts from three ethnic groups : Chinese, Malays, and Indians received a weekly regimen of naltrexone (100 mg on Day 1 and 3 and 150 mg on Day 5). Subjects were randomly assigned to receive intravenous challenge with either 25 mg heroin or placebo 12, 24, 48, and 72 h after the third naltrexone dose. Physiological and subjective parameters were measured at each challenge interval. Results indicated that naltrexone was effective in blocking the physiological and psychological effects of heroin for at least 48 and 72 h, respectively, in detoxified Malaysian opiate addicts. The efficacy of naltrexone did not differ among the three ethnic groups evaluated in this study.
Affiliation :
Nat. Drug Res. Ctr, Univ. Sains Malayia, Minden, 11800 Pulau Pinang
Malaisie. Malaya.
Malaisie. Malaya.