Historique
Périodique
The effects of high and low doses of methadone on cigarette smoking
(Action de la méthadone à faible dose et à forte dose, sur le tabagisme)
Auteur(s) :
SCHMITZ, J. M. ;
GRABOWSKI, J. ;
RHOADES, H.
Année
1994
Langue(s) :
Anglais
ISBN :
0376-8716
Refs biblio. :
16
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
TABAC
;
INTERACTION CHIMIQUE
;
METHADONE
;
CONSOMMATION
;
TRAITEMENT DE MAINTENANCE
Note générale :
Drug and Alcohol Dependence , 1994, 364, 237-242
Résumé :
FRANÇAIS :
La consommation de cigarettes est testée chez cinq patients en traitement de maintenance depuis 6 mois, et à qui on administre, par période de deux semaines alternées, des doses croissantes ou décroissantes de méthadone. Les patients enregistrent eux-mêmes leur consommation de cigarettes. De ces données, il ressort que la proportion de cigarettes fumées quotidiennement est plus importante quatre heures après l'ingestion de méthadone pour trois des cinq patients.
ENGLISH :
The effect of methadone dose on the cigarette smoking of five methadone maintenance subjects was studied in a clinical setting. Following a two-week baseline period, daily doses of methadone were either increased (50-80 mg) or decreased (80-50 mg) every two weeks according to an A-B-A-B study design. Continuous self-monitoring was used to collect data on natural smoking behevior, and expired air carbon monoxide (CO) levels were measured at each clinic visit. The predicted methadone dose-related changes in smoking were found in three of the five subjects. Fine-grained analysis of self-monitoring records showed that the proportion of total daily smoking was highest within 4 h after taking methadone for three sujects. CO levels were not significantly associated with smoking rate. The results further support and extend previous reports that methadone may produce dose-related increases in smoking.
La consommation de cigarettes est testée chez cinq patients en traitement de maintenance depuis 6 mois, et à qui on administre, par période de deux semaines alternées, des doses croissantes ou décroissantes de méthadone. Les patients enregistrent eux-mêmes leur consommation de cigarettes. De ces données, il ressort que la proportion de cigarettes fumées quotidiennement est plus importante quatre heures après l'ingestion de méthadone pour trois des cinq patients.
ENGLISH :
The effect of methadone dose on the cigarette smoking of five methadone maintenance subjects was studied in a clinical setting. Following a two-week baseline period, daily doses of methadone were either increased (50-80 mg) or decreased (80-50 mg) every two weeks according to an A-B-A-B study design. Continuous self-monitoring was used to collect data on natural smoking behevior, and expired air carbon monoxide (CO) levels were measured at each clinic visit. The predicted methadone dose-related changes in smoking were found in three of the five subjects. Fine-grained analysis of self-monitoring records showed that the proportion of total daily smoking was highest within 4 h after taking methadone for three sujects. CO levels were not significantly associated with smoking rate. The results further support and extend previous reports that methadone may produce dose-related increases in smoking.
Affiliation :
Univ. Texas Ment. Sci. Inst. , 1300 Moursund, Huston, TX 77030
Etats-Unis. United States.
Etats-Unis. United States.