Historique
Périodique
Disposition of heroin and its metabolites in heroin-related deaths
(Caractéristique de l'héroïne et de ses métabolites dans les cas de morts dues à l'héroïne)
Auteur(s) :
GOLDBERGER, B. A. ;
CONE, E. J. ;
GRANT, T. M. ;
CAPLAN, Y. H. ;
LEVINE, B. S. ;
SMIALEK J.E.
Année
1994
Langue(s) :
Anglais
ISBN :
0146-4760
Refs biblio. :
23
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Journal of Analytical Toxicology, 1994, 18, 22-28
Résumé :
FRANÇAIS :
A partir de décès dûs à l'héroïne, 21 échantillons de sang et d'urine ont été recueillis. La mort, dans les cas étudiés était rapide, tardive ou indéterminée. Ces différents types de mort déterminent le taux de concentration de l'héroïne et ses métabolites dans le sang, les urines et les autres tissus (liquide cérébrospinal, foie, poumons, reins). Tous les spécimens étaient positifs à la morphine. Les métabolites de l'héroïne ont été détectés dans les cheveux. Ces études démontrent l'utilité du dépistage de l'héroïne dans le diagnostic des décès dûs à cette substance.
ENGLISH :
From heroin-related deaths, 21 sets of blood and urine specimens were collected. The mode of death in these cases was categorized as rapid, delayed, or undetermined. Compared with delayed deaths, rapid deaths were characterized by the following trends: higher mean concentrations of 6-acetylmorphine, free morphine, and total opiates in blood; a higher ratio of free morphine concentrations to total opiate concentrations in blood; lower mean concentrations of 6-acetylmorphine and morphine in urine; greater likelihood of 6-acetylmorphine detection in blood, and lesser likelihood of heroin detection in urine. The study also included analysis of multiple tissue specimens from two subjects who died of heroin intoxication. Heroin was identified in urine and injection-site tissue. Concentrations of 6-acetylmorphine in cerebrospinal fluid, spleen, and brain were substantially higher than in blood, liver, lung, and kidney. All specimens were positive for morphine. Heroin metabolites were detected in hair specimens. The identification of heroin and 6-acetylmorphine in biological tissues effectively established the presence of heroin in cases of acute narcotic intoxication. These studies demonstrated that measurement of heroin and its metabolites provides usefu metabolites provides useful information for the differential diagnosis of heroin-related deaths. information for the
A partir de décès dûs à l'héroïne, 21 échantillons de sang et d'urine ont été recueillis. La mort, dans les cas étudiés était rapide, tardive ou indéterminée. Ces différents types de mort déterminent le taux de concentration de l'héroïne et ses métabolites dans le sang, les urines et les autres tissus (liquide cérébrospinal, foie, poumons, reins). Tous les spécimens étaient positifs à la morphine. Les métabolites de l'héroïne ont été détectés dans les cheveux. Ces études démontrent l'utilité du dépistage de l'héroïne dans le diagnostic des décès dûs à cette substance.
ENGLISH :
From heroin-related deaths, 21 sets of blood and urine specimens were collected. The mode of death in these cases was categorized as rapid, delayed, or undetermined. Compared with delayed deaths, rapid deaths were characterized by the following trends: higher mean concentrations of 6-acetylmorphine, free morphine, and total opiates in blood; a higher ratio of free morphine concentrations to total opiate concentrations in blood; lower mean concentrations of 6-acetylmorphine and morphine in urine; greater likelihood of 6-acetylmorphine detection in blood, and lesser likelihood of heroin detection in urine. The study also included analysis of multiple tissue specimens from two subjects who died of heroin intoxication. Heroin was identified in urine and injection-site tissue. Concentrations of 6-acetylmorphine in cerebrospinal fluid, spleen, and brain were substantially higher than in blood, liver, lung, and kidney. All specimens were positive for morphine. Heroin metabolites were detected in hair specimens. The identification of heroin and 6-acetylmorphine in biological tissues effectively established the presence of heroin in cases of acute narcotic intoxication. These studies demonstrated that measurement of heroin and its metabolites provides usefu metabolites provides useful information for the differential diagnosis of heroin-related deaths. information for the
Affiliation :
Addict. Res. Ctr, NIDA, PO Box 5180, Baltimore, MD 21224
Etats-Unis. United States.
Etats-Unis. United States.