Historique
Périodique
Discriminative stimulus effects of phencyclidine : pharmacologically specific interactions with delta9 and delta8 tetrahydrocannabinol
(Effet de stimulus discriminatoire de la phéncyclidine : interactions pharmacologiques spécifiques avec le delta9 et delta8 tétrahydrocannabinol)
Auteur(s) :
DOTY P. ;
DYSTRA L. A. ;
PICKER M. J.
Année
1994
Langue(s) :
Anglais
ISBN :
0376-8716
Refs biblio. :
34
Domaine :
Drogues illicites
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
INTERACTION CHIMIQUE
;
PHENCYCLIDINE
;
TETRAHYDROCANNABINOL
;
CONDITIONNEMENT
;
MODELE ANIMAL
Note générale :
Drug and Alcohol Dependence, 1994, 35, 151-158
Résumé :
FRANÇAIS :
Des expériences menées sur des rats entraînés à discriminer la phéncyclidine, montrent que le delta9 et delta8 tétrahydrocannabinol atténuent l'effet de stimulus discriminatoire de la PCP, effet que l'on obtient pas avec la morphine, la d-amphétamine et le chlordiazepoxide.
ENGLISH :
Rats were trained to discriminate a dose of 1.75 mg/kg phencyclidine (PCP) from saline. During substitution tests, both PCP and the noncompetitive NMDA antagonist, MK-801 substituted for the PCP stimulus in a dose-dependent manner. In contrast, delta9-tetrahydrocannabinol (delta9-THC) and delta8-tetrahydrocannabinol (delta8-THC) failed to substitute for the PCP stimulus, up to doses that substantially decreased rate of responding. However, both delta9-THC and delta 8THC partially attenuated the discriminative stimulus effects of the PCP training dose. In contrast to the effects observed with delta9THC and delta8-THC, morphine, d-amphetamine and chlordiazepoxide failed to attenuate the discriminative stimulus effects of PCP, even at doses that markedly decreased rate of responding. The present findings suggest that delta 9-THC and delta8-THC alter the discriminative stimulus effects of PCP in a pharmacologically specific manner.
Des expériences menées sur des rats entraînés à discriminer la phéncyclidine, montrent que le delta9 et delta8 tétrahydrocannabinol atténuent l'effet de stimulus discriminatoire de la PCP, effet que l'on obtient pas avec la morphine, la d-amphétamine et le chlordiazepoxide.
ENGLISH :
Rats were trained to discriminate a dose of 1.75 mg/kg phencyclidine (PCP) from saline. During substitution tests, both PCP and the noncompetitive NMDA antagonist, MK-801 substituted for the PCP stimulus in a dose-dependent manner. In contrast, delta9-tetrahydrocannabinol (delta9-THC) and delta8-tetrahydrocannabinol (delta8-THC) failed to substitute for the PCP stimulus, up to doses that substantially decreased rate of responding. However, both delta9-THC and delta 8THC partially attenuated the discriminative stimulus effects of the PCP training dose. In contrast to the effects observed with delta9THC and delta8-THC, morphine, d-amphetamine and chlordiazepoxide failed to attenuate the discriminative stimulus effects of PCP, even at doses that markedly decreased rate of responding. The present findings suggest that delta 9-THC and delta8-THC alter the discriminative stimulus effects of PCP in a pharmacologically specific manner.
Affiliation :
Dept Psychiatr. , Univ. Chicago, MC 3077 5841 S. Maryland Ave, Chicago IL 60637
Etats-Unis. United States.
Etats-Unis. United States.