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Cocaine abuse in methadone maintenance patients is associated with low serum methadone concentrations
(L'abus de cocaïne chez les patients sous méthadone est associé à de basses concentrations de méthadone sérique)
Auteur(s) :
TENNANT, F. ;
SHANNON, J.
Année
1995
Langue(s) :
Anglais
ISBN :
1055-0887
Refs biblio. :
34
Domaine :
Drogues illicites / Illicit drugs
Note générale :
Journal of Addictive Diseases, 1995, 14, (1), 67-74
Résumé :
FRANÇAIS :
La consommation de cocaïne est étudiée chez 74 patients recevant quotidiennement 30 à 80 mg/j de méthadone. 28% cessent leur usage de cocaïne quand on augmente la dose de méthadone à 160 mg/j. La mesure de la concentration sérique de méthadone montre que la consommation de cocaïne semble accélérer l'élimination de la méthadone. Des traitements alternatifs à l'augmentation des doses de méthadone doivent être mis au point.
ENGLISH :
74 methadone maintenance patients maintained at daily dosages between 30 and 80 mg and who chronically abused cocaine were studied by a standard protocol. A total of 21 subjects ceased cocaine abuse when their methadone dosage was progressively raised to a maximal daily dose of 160 mg. Cocaine abuse appeared to accelerate elimination of methadone, since inadequate methadone serum concentrations were found in 48 of 67 subjects tested 24 hours after a 100 mg oral methadone dose. Alternative treatments for cocaine abuse in methadone maintenance patients must be identified since cocaine abuse may lower serum methadone concentrations. (From authors' abstract)
La consommation de cocaïne est étudiée chez 74 patients recevant quotidiennement 30 à 80 mg/j de méthadone. 28% cessent leur usage de cocaïne quand on augmente la dose de méthadone à 160 mg/j. La mesure de la concentration sérique de méthadone montre que la consommation de cocaïne semble accélérer l'élimination de la méthadone. Des traitements alternatifs à l'augmentation des doses de méthadone doivent être mis au point.
ENGLISH :
74 methadone maintenance patients maintained at daily dosages between 30 and 80 mg and who chronically abused cocaine were studied by a standard protocol. A total of 21 subjects ceased cocaine abuse when their methadone dosage was progressively raised to a maximal daily dose of 160 mg. Cocaine abuse appeared to accelerate elimination of methadone, since inadequate methadone serum concentrations were found in 48 of 67 subjects tested 24 hours after a 100 mg oral methadone dose. Alternative treatments for cocaine abuse in methadone maintenance patients must be identified since cocaine abuse may lower serum methadone concentrations. (From authors' abstract)
Affiliation :
Res. Ctr Depend. Disorders, 336 1/2 South Glendora Ave, West Covina, CA 91790
Etats-Unis. United States.
Etats-Unis. United States.