Historique
Périodique
Effect of cocaine on vagal tone: a common factors approach
(Action de la cocaïne sur le tonus vagal: approche des facteurs communs à plusieurs drogues)
Auteur(s) :
NEWLIN, D. B.
Année
1995
Langue(s) :
Anglais
ISBN :
0376-8716
Refs biblio. :
25
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
COCAINE
;
APPAREIL CARDIOVASCULAIRE
;
SYSTEME NERVEUX AUTONOME
;
POTENTIEL ADDICTIF
Note générale :
Drug and Alcohol Dependence, 1995, 37, 211-216
Résumé :
FRANÇAIS :
Une injection ce cocaïne de 40mg entraine une augmentation de la vitesse du coeur de 30 battements/mn et simultanément, le tonus vagal diminue de deux unités. Ces résultats signifient qu'il existe, théoriquement, un facteur commun à beaucoup de drogues illicites. Ceci peut servir à déterminer le potentiel toxique d'une substance, bien que les limites de cette approche soient nombreuses.
ENGLISH :
This paper discusses a distinct cardiovascular pattern that is common to a wide variety of abused substances. The pattern consists of tachycardia that appears mediated by withdrawal of vagal inhibition, as indicated by decreases in cardiac vagal tone. This decrease in vagal tone was particularly robust with i.v. cocaine given to experienced abusers. Following 40mg i.v. cocaine, heart rate increased by approximately 30 beats/mn at the same time that vagal tone decreased by 2 log/mn. The theoretical significance of these findings is based on evidence that the results reflects a common factor among many abused drugs, but not the few aversive drugs that have been studied in this paradigm. (From author's abstract)
Une injection ce cocaïne de 40mg entraine une augmentation de la vitesse du coeur de 30 battements/mn et simultanément, le tonus vagal diminue de deux unités. Ces résultats signifient qu'il existe, théoriquement, un facteur commun à beaucoup de drogues illicites. Ceci peut servir à déterminer le potentiel toxique d'une substance, bien que les limites de cette approche soient nombreuses.
ENGLISH :
This paper discusses a distinct cardiovascular pattern that is common to a wide variety of abused substances. The pattern consists of tachycardia that appears mediated by withdrawal of vagal inhibition, as indicated by decreases in cardiac vagal tone. This decrease in vagal tone was particularly robust with i.v. cocaine given to experienced abusers. Following 40mg i.v. cocaine, heart rate increased by approximately 30 beats/mn at the same time that vagal tone decreased by 2 log/mn. The theoretical significance of these findings is based on evidence that the results reflects a common factor among many abused drugs, but not the few aversive drugs that have been studied in this paradigm. (From author's abstract)
Affiliation :
NIDA Intramural Res. Prog., Baltimore, MD
Etats-Unis. United States.
Etats-Unis. United States.