Historique
Périodique
The role of dopamine in drug abuse viewed from the perspective of its role in motivation
(Le rôle de la dopamine dans la toxicomanie particulièrement au niveau de la motivation)
Auteur(s) :
DI CHIARA G.
Année
1995
Langue(s) :
Anglais
ISBN :
0376-8716
Refs biblio. :
500
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Drug and Alcohol Dependence, 1995, 38, 95-137
Résumé :
FRANÇAIS :
La dopamine est un neurotransmetteur impliqué dans trois aspects majoritaires de la motivation: modulation, acquisition et expression. Les drogues illicites stimulent la transmission de la dopamine dans le striatum. Celle-ci n'induit pas le premier stimulus répondant à l'auto-administration (sauf pour les stimulants), mais est essentielle dans l'activation des propriétés des différentes drogues et est l'instrument d'acquisition des réponses aux stimuli liés aux drogues. Le sevrage entraine une réduction de la transmission de la dopamine et une réduction de la réponse aux agents de renforcement.
ENGLISH :
Dopamine is recognized as the transmitter being involved in at least three major aspects of motivation: modulation of motivational state, acquisition and expression of incentive properties by motivational stimuli. Apart of psychostimulants, the evidence that stimulation of dopamine transmission by drugs provides the primary motivational stimulus for drug self-administration is either unconvincing or negative. However, stimulation of dopamine transmission is essential for the activation properties of drugs and might be instrumental for the acquisition of responding to drug-related incentive stimuli. Dopamine is involved in induction and the expression of behavioral sensitization by repeated exposure to various drugs of abuse. Withdrawal results in a reduction in basal dopamine transmission in vivo and in reduced responding for conventional reinforcers. (From author's abstract)
La dopamine est un neurotransmetteur impliqué dans trois aspects majoritaires de la motivation: modulation, acquisition et expression. Les drogues illicites stimulent la transmission de la dopamine dans le striatum. Celle-ci n'induit pas le premier stimulus répondant à l'auto-administration (sauf pour les stimulants), mais est essentielle dans l'activation des propriétés des différentes drogues et est l'instrument d'acquisition des réponses aux stimuli liés aux drogues. Le sevrage entraine une réduction de la transmission de la dopamine et une réduction de la réponse aux agents de renforcement.
ENGLISH :
Dopamine is recognized as the transmitter being involved in at least three major aspects of motivation: modulation of motivational state, acquisition and expression of incentive properties by motivational stimuli. Apart of psychostimulants, the evidence that stimulation of dopamine transmission by drugs provides the primary motivational stimulus for drug self-administration is either unconvincing or negative. However, stimulation of dopamine transmission is essential for the activation properties of drugs and might be instrumental for the acquisition of responding to drug-related incentive stimuli. Dopamine is involved in induction and the expression of behavioral sensitization by repeated exposure to various drugs of abuse. Withdrawal results in a reduction in basal dopamine transmission in vivo and in reduced responding for conventional reinforcers. (From author's abstract)
Affiliation :
Dept Toxicol., Univ. Cagliari, Viale A. Diaz, 182, 09126 Cagliari
Italie. Italy.
Italie. Italy.