Historique
Article de Périodique
Hostility in heroin abusers subtypes: fluoxetine and naltrexone treatment (1995)
(Agressivité chez les héroïnomanes : traitement par la fluoxétine et la naltrexone)
Auteur(s) :
GERRA, G. ;
FERTONANI, G. ;
ZAIMOVIC, A. ;
ROTA-GRAZIOSI, I. ;
AVANZINI, P. ;
CACCAVARI, R. ;
DELSIGNORE, R. ;
LUCCHINI A.
Année
1995
Page(s) :
1225-1237
Langue(s) :
Anglais
Refs biblio. :
44
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PSY (Psychopathologie / Psychopathology)
Thésaurus mots-clés
HEROINE
;
DEPENDANCE
;
AGRESSIVITE
;
COMPORTEMENT
;
DEPRESSION
;
ANTIDEPRESSEURS
Résumé :
FRANÇAIS :
Les inhibiteurs de la recapture de la sérotonine peuvent être considérés comme des médicaments d'avenir pour le traitement des dépendances. Toutefois, les variations de groupes de toxicomanes montrent que la naltrexone entraine un taux de rechutes qui peut être attribué aux troubles psychologiques associés à l'usage de drogue et qui sont responsables des symptômes cliniques au cours des phases du post-sevrage.
ENGLISH :
1. Substance abusers subtypes have been identified considering underlying psychobiological disorder, familial factors, age of onset, legal problems and drug of choice. 2. In the present study the authors submitted 98 male heroin addicted individuals (age 19-28 y) to the Buss Durkee Hostility Inventory (Italian version) and a structured interview concerning social and clinical history; legal problems, age of onset of drug abuse, drug of choice. 3. Serotonergic system sensitivity was evaluated with fenfluramine challenge for PRL assay. 4. Thirty two patients (group A) showed high score for resentment and guilt at BDHI (hostility in), low rate of legal problems, late age of onset, preference for heroin and alcohol. Twenty nine patients (group B) showed high score for assault and irritability at BDHI (hostility out), high rate of legal problems, early age of onset, preference for heroin and cocaine. The other 37 patients (group C) showed aggression score in the normal range at BDHI, no legal problems, late onset of substance abuse, preference for heroin only. 5. PRL responses was blunted in group A (p < 0.001) and significantly decreased in group B (p < 0.05). PRL plasma levels were inversely correlated with HRSD scores. 6. All the patients were included in a treatment protocol with fluoxetine and naltrexone or placebo and naltrexone for 6 months. 7. The treatment was effective in group A with a significant improvement of BDHI results and decrease of craving score, lower level of drop out, lower level of positive urine controls. No significant differences between fluoxetine and placebo effects have been evidenced in patients of group B and C. The present findings suggest that psychopharmacological approach to addiction needs a diagnostic screening for specific subtypes.
Les inhibiteurs de la recapture de la sérotonine peuvent être considérés comme des médicaments d'avenir pour le traitement des dépendances. Toutefois, les variations de groupes de toxicomanes montrent que la naltrexone entraine un taux de rechutes qui peut être attribué aux troubles psychologiques associés à l'usage de drogue et qui sont responsables des symptômes cliniques au cours des phases du post-sevrage.
ENGLISH :
1. Substance abusers subtypes have been identified considering underlying psychobiological disorder, familial factors, age of onset, legal problems and drug of choice. 2. In the present study the authors submitted 98 male heroin addicted individuals (age 19-28 y) to the Buss Durkee Hostility Inventory (Italian version) and a structured interview concerning social and clinical history; legal problems, age of onset of drug abuse, drug of choice. 3. Serotonergic system sensitivity was evaluated with fenfluramine challenge for PRL assay. 4. Thirty two patients (group A) showed high score for resentment and guilt at BDHI (hostility in), low rate of legal problems, late age of onset, preference for heroin and alcohol. Twenty nine patients (group B) showed high score for assault and irritability at BDHI (hostility out), high rate of legal problems, early age of onset, preference for heroin and cocaine. The other 37 patients (group C) showed aggression score in the normal range at BDHI, no legal problems, late onset of substance abuse, preference for heroin only. 5. PRL responses was blunted in group A (p < 0.001) and significantly decreased in group B (p < 0.05). PRL plasma levels were inversely correlated with HRSD scores. 6. All the patients were included in a treatment protocol with fluoxetine and naltrexone or placebo and naltrexone for 6 months. 7. The treatment was effective in group A with a significant improvement of BDHI results and decrease of craving score, lower level of drop out, lower level of positive urine controls. No significant differences between fluoxetine and placebo effects have been evidenced in patients of group B and C. The present findings suggest that psychopharmacological approach to addiction needs a diagnostic screening for specific subtypes.
Affiliation :
Addict. Res. Ctr, Ser.T.-A.U.S.L. Parma
Italie. Italy.
Italie. Italy.