Historique
Article de Périodique
Flupentixol-induced aversion to crack cocaine (1996)
Auteur(s) :
GAWIN F. H. ;
KHALSA-DENISON M. E. ;
JATLOW P.
Année
1996
Page(s) :
1340-1341
Langue(s) :
Anglais
Refs biblio. :
4
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
New England Journal of Medicine, 1996, 334, (20), 1340-1341
Résumé :
FRANÇAIS :
A faible dose, le flupentixol a des propriétés antidépressives mais pas de propriétés neuroleptiques. Il peut être utilisé dans le traitement du manque de cocaïne. Il produit une aversion pour la cocaïne et le crack, réversible et sans danger. [Résumé Toxibase]
ENGLISH:
Disulfiram causes an aversive response to alcohol that is used therapeutically to foster abstinence. There is no similarly effective and safe aversive treatment for cocaine abuse. We report here that flupentixol decanoate can cause transient, severely distressing, involuntary muscular restlessness and movement (akathisia) after crack-cocaine smoking that is associated with the subsequent cessation of crack use. Flupentixol is a neuroleptic at high plasma concentrations but has nonneuroleptic, antidepressant activity at low concentrations,1 a characteristic that provides the basis for its use in treating cocaine craving and abuse. In injectable depot form, it has a duration of action of approximately 14 days. [Extract]
A faible dose, le flupentixol a des propriétés antidépressives mais pas de propriétés neuroleptiques. Il peut être utilisé dans le traitement du manque de cocaïne. Il produit une aversion pour la cocaïne et le crack, réversible et sans danger. [Résumé Toxibase]
ENGLISH:
Disulfiram causes an aversive response to alcohol that is used therapeutically to foster abstinence. There is no similarly effective and safe aversive treatment for cocaine abuse. We report here that flupentixol decanoate can cause transient, severely distressing, involuntary muscular restlessness and movement (akathisia) after crack-cocaine smoking that is associated with the subsequent cessation of crack use. Flupentixol is a neuroleptic at high plasma concentrations but has nonneuroleptic, antidepressant activity at low concentrations,1 a characteristic that provides the basis for its use in treating cocaine craving and abuse. In injectable depot form, it has a duration of action of approximately 14 days. [Extract]
Affiliation :
Mood Addict. Neurosci. Found., Los Angeles, CA 90025
Etats-Unis. United States.
Etats-Unis. United States.