Historique
Périodique
Delta 8-Tetrahydrocannabinol p-quinone as an air oxidation product of Delta 8-Tetrahydrocannabinol and its biological and pharmacological effects in mice
(La Delta 8-Tétrahydrocannabinol p-quinone, produit d'oxydation du Delta 8-Tétrahydrocannabinol et ses effets biologiques et pharmacologiques chez la souris)
Auteur(s) :
USAMI N. ;
WATANABE K. ;
YAMAMOTO I. ;
YOSHIMURA H.
Année
1997
Langue(s) :
Anglais
ISBN :
1080-8388
Refs biblio. :
18
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
CANNABIS
;
TETRAHYDROCANNABINOL
;
CANNABINOIDES
;
ENZYMES
;
MECANISME D'ACTION
;
PHARMACOLOGIE
;
METABOLISME
;
MESURES QUANTITATIVES
;
FOIE
Note générale :
Research Communications in Alcohol and Substances of Abuse, 1997, 18, (3/4), 125-139
Résumé :
FRANÇAIS :
La Delta 8-tétrahydrocannabinol p-quinone est un produit d'oxydation de Delta 8-THC, qui a des effets biologiques et pharmacologiques. Elle inhibe de manière significative les activités enzymatiques des microsomes hépatiques, particulièrement celle de l'aminopyrine-Ndéméthylase et de la microsome aldéhyde oxygènase. Mais les effets de la quinone sont moins importants que ceux du Delta 8-THC.
ENGLISH :
Delta 8-Tetrahydrocannabinol p-quinone (delta 8-THCPQ) was identified as an air oxydation product of delta 8-THC, and its biological and pharmacological properties were compared with those of delta 8-THC. Delta 8-THCPQ significantly inhibited the activities of microsomal aminopyrine N-demethylase and microsomal aldehyde oxygenase, in a concentration-dependent manner. Thus, the effects of the quinone were lesser extent that those of Delta 8-THC, and also suggests that the quinone derivatives may possess toxicological effects in the case of long intake of marihuana. (From authors' abstract)
La Delta 8-tétrahydrocannabinol p-quinone est un produit d'oxydation de Delta 8-THC, qui a des effets biologiques et pharmacologiques. Elle inhibe de manière significative les activités enzymatiques des microsomes hépatiques, particulièrement celle de l'aminopyrine-Ndéméthylase et de la microsome aldéhyde oxygènase. Mais les effets de la quinone sont moins importants que ceux du Delta 8-THC.
ENGLISH :
Delta 8-Tetrahydrocannabinol p-quinone (delta 8-THCPQ) was identified as an air oxydation product of delta 8-THC, and its biological and pharmacological properties were compared with those of delta 8-THC. Delta 8-THCPQ significantly inhibited the activities of microsomal aminopyrine N-demethylase and microsomal aldehyde oxygenase, in a concentration-dependent manner. Thus, the effects of the quinone were lesser extent that those of Delta 8-THC, and also suggests that the quinone derivatives may possess toxicological effects in the case of long intake of marihuana. (From authors' abstract)
Affiliation :
Fac. Pharm. Sci., Hokuriku Univ., Kanasawa 920-11
Japon. Japan.
Japon. Japan.