A comparison of subjective, psychomotor and physiological effects of novel muscarinic analgesic, LY297802 tartrate, and oral morphine in occasional drug users

FRANÇAIS :
Chez des volontaires, usagers occasionnels, on a administré du tartrate LY297802, de la morphine ou un placebo, en 9 sessions expérimentales. Les effets subjectifs sont mesurés sur l'échelle VAS (Visual Analog Scale), l'ARCI (Addiction Research Center Inventory) et l'ARS (Adjective Rating Scale); les performances psychomotrices sont mesurées à l'aide du test DSST (Digit Symbol Substitution Test). Seule la morphine orale entraine une augmentation significative de certains effets subjectifs. La morphine a des effets dode-dépendants sur les performances du DSST: vitesse du coeur, saturation en oxygène du sang, diamètre de la pupille; le LY 297802 a également certains de ces effets physiologiques: augmentation de la vitesse cardiaque, de la pression artérielle et diastolique.
ENGLISH :
This study compared the subjective, physiological and psychomotor effects of a novel muscarinic analgesic (LY297802) and oral morphine in healthy volonteers. Nine occasional drug users participated in nine experimental sessions in which they received oral LY297802 and oral morphine. Subjective drug effects were assessed using the Visual Analog Scale (VAS), the Addiction Research Center Inventory (ARCI) and the Adjective Rating Scale (ARS). Oral morphine produced significant increases in some subjective effects scales, including elevations on the VAS, ARCI and ARS. LY297802 did not engender changes different from placebo on any of these indices. The result suggest that LY297802 does not induce subjective effects similar to morphine, but that it has some significant physiological effects. (From authors' abstract)