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Buprenorphine and carbamazepine as a treatment for detoxification of opiate addicts with multiple drug misuse: a pilot study
(La buprénorphine et la carbamazépine dans la désintoxication des usagers d'opiacés polytoxicomanes : une étude pilote.)
Auteur(s) :
SCHNEIDER, U. ;
PAETZOLD W. ;
ERONAT V. ;
HUBER, T. J. ;
SEIFERT, J. ;
WIESE, B. ;
EMRICH, H. M.
Année
2000
Page(s) :
65-69
Langue(s) :
Anglais
Refs biblio. :
26
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
OPIACES
;
DESINTOXICATION
;
POLYCONSOMMATION
;
CURE DE DESINTOXICATION
;
ANTICONVULSIVANTS
;
BUPRENORPHINE
;
EFFICACITE
Note générale :
Addiction Biology, 2000, 5, (1), 65-69
Note de contenu :
fig. ; tabl.
Résumé :
FRANÇAIS :
Les usagers d'opiacés tendant de plus en plus vers la polytoxicomanie, de nouvelles stratégies de desintoxication sont à envisager afin de prévenir les complications létales et de diminuer les symptômes de sevrage. Deux protocoles de désintoxication ont été comparés chez 27 hommes et femmes dépendant des opiacés et polytoxicomanes : 15 d'entre eux ont reçu pendant 10 jours des faibles doses de buprénorphine et pendant 19 jours de la carbamazépine ; 12 d'entre eux ont reçu pendant 14 jours de l'oxazépam et pendant 19 jours de la carbamazépine. L'association de buprénorphine et de carbamazépine a permis un meilleur soulagement des symptômes de sevrage au cours de la première semaine de traitement. Dans les deux groupes, aucun effet secondaire grave n'est survenu.
ENGLISH :
The growing tendency of opioid addicts to misuse multiple other drugs leads to the investigation of new pharmacostrategies to prevent patients from suffering life-threatening complications and minimize the withdrawal symptoms. The short-term efficacy of a 10-day low-dose buprenorphine/19-day carbamazepine regime (n = 15) to a 14-day oxazepam/19-day carbamazepine regime (n = 12) in an open-labelled 21-day inpatient detoxification treatment was compared. Twenty-seven men and women dependent on opioids and misusing other drugs admitted to a detoxification unit were included in this protocol. Eighteen of 27 patients (67%) completed the study. Four non-completers (27%) received buprenorphine/carbamazepine (four of 15) and five non-completers (42%) were treated with oxazepam/carbamzepine (five of 12), but the difference in the dropout rate between the two treatment strategies was not significant. The buprenorphine/carbamazepine regime provided significantly more effective relief of withdrawal symptoms during the first week of treatment. No severe side effects occurred during treatment in both groups. The present study supports the hypothesis that buprenorphine/carbamazepine is more effective than oxazepam/carbamazepine in rapid opioid detoxification in patients with additional multiple drug misuse and both regimens were safe with no unexpected side effects. (Author' s abstract)
Les usagers d'opiacés tendant de plus en plus vers la polytoxicomanie, de nouvelles stratégies de desintoxication sont à envisager afin de prévenir les complications létales et de diminuer les symptômes de sevrage. Deux protocoles de désintoxication ont été comparés chez 27 hommes et femmes dépendant des opiacés et polytoxicomanes : 15 d'entre eux ont reçu pendant 10 jours des faibles doses de buprénorphine et pendant 19 jours de la carbamazépine ; 12 d'entre eux ont reçu pendant 14 jours de l'oxazépam et pendant 19 jours de la carbamazépine. L'association de buprénorphine et de carbamazépine a permis un meilleur soulagement des symptômes de sevrage au cours de la première semaine de traitement. Dans les deux groupes, aucun effet secondaire grave n'est survenu.
ENGLISH :
The growing tendency of opioid addicts to misuse multiple other drugs leads to the investigation of new pharmacostrategies to prevent patients from suffering life-threatening complications and minimize the withdrawal symptoms. The short-term efficacy of a 10-day low-dose buprenorphine/19-day carbamazepine regime (n = 15) to a 14-day oxazepam/19-day carbamazepine regime (n = 12) in an open-labelled 21-day inpatient detoxification treatment was compared. Twenty-seven men and women dependent on opioids and misusing other drugs admitted to a detoxification unit were included in this protocol. Eighteen of 27 patients (67%) completed the study. Four non-completers (27%) received buprenorphine/carbamazepine (four of 15) and five non-completers (42%) were treated with oxazepam/carbamzepine (five of 12), but the difference in the dropout rate between the two treatment strategies was not significant. The buprenorphine/carbamazepine regime provided significantly more effective relief of withdrawal symptoms during the first week of treatment. No severe side effects occurred during treatment in both groups. The present study supports the hypothesis that buprenorphine/carbamazepine is more effective than oxazepam/carbamazepine in rapid opioid detoxification in patients with additional multiple drug misuse and both regimens were safe with no unexpected side effects. (Author' s abstract)
Affiliation :
Dept Clin. Psychiat. Psychother., Sch. Med., 30625 Hannover
Allemagne. Germany.
Allemagne. Germany.