Historique
Article de Périodique
Elevated central serotonin transporter binding availability in acutely abstinent cocaine-dependent patients (2000)
(Disponibilité des transporteurs centraux de la serotonine chez des cocaïnomanes abstinents)
Auteur(s) :
JACOBSEN, L. K. ;
STALEY, J. K. ;
MALISON R. T. ;
ZOGHBI, S. S. ;
SEIBYL J. P. ;
KOSTEN, T. R. ;
INNIS R. B.
Année
2000
Page(s) :
1134-1140
Langue(s) :
Anglais
Refs biblio. :
59
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
COCAINE
;
NEUROBIOLOGIE
;
SEROTONINE
;
DOPAMINE
;
ABSTINENCE
;
NEUROTRANSMETTEURS
;
MECANISME D'ACTION
Résumé :
Objective: Recent work has underscored the role of serotonergic neurotransmission in chronic neural adaptations to cocaine dependence. The authors tested for evidence of serotonergic dysfunction during acute abstinence from cocaine, a period of high risk for relapse in cocaine dependence. Method: Binding availability of dopamine transporters and serotonin transporters was measured in 15 cocaine-dependent subjects during acute abstinence and in 37 healthy comparison subjects by using [123]b-CIT and single photon emission computed tomography. Results: Significant increases in diencephalic and brainstem serotonin transporter binding (16.7% and 31.6%, respectively) were observed in cocaine-dependent subjects. Brainstem serotonin transporter binding was significantly inversely correlated with age across diagnostic groups. Conclusions: These findings provide futher evidence of serotonergic dysfunction during acute abstinence from chronic cocaine use. Age-related decline in brainstem serotonin transporter binding may underlie the poor response to selective serotonin reuptake inhibitor antidepressants seen in some elderly depressed patients. (Author's abstract.)
Affiliation :
Psychiatry 116A, 950 Campbell ave., West Haven, CT 06516
leslie.jacobsenyale.edu
Etats-Unis. United States.
leslie.jacobsenyale.edu
Etats-Unis. United States.