Historique
Périodique
Heroin overdose: causes and consequences
(Overdose d'héroïne : causes et conséquences)
Auteur(s) :
WARNER-SMITH, M. ;
DARKE, S. ;
LYNSKEY, M. ;
HALL, W.
Année
2001
Page(s) :
1113-1125
Langue(s) :
Anglais
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
HEROINE
;
SURDOSE
;
MORT
;
ETIOLOGIE
;
FACTEUR DE RISQUE
;
POLYCONSOMMATION
;
PATHOLOGIE ORGANIQUE
Note générale :
Addiction, 2001, 96, (8), 1113-1125
Résumé :
Over the past decade fatal opioid overdose has emerged as a major public health issue internationally. This paper examines the risk factors for overdose from a biomedical perspective. While significant risk factors for opioid overdose fatality are well recognized, the mechanism of fatal overdose remains unclear. Losses of tolerance and concomitant use of alcohol and other CNS depressants clearly play a major role in fatality; however, such rich risk factors do not account for the strong age and gender patterns observed consistently among victims of overdose. There is evidence that systemic disease may be more prevalent in users at greatest risk of overdose. We hypothesize that pulmonary and hepatic dysfunction resulting from such disease may increase susceptibility to both fatal and non-fatal overdose. Sequelae of non-fatal overdose are recognized in the clinical literature but few epidemiological data exist describing the burden of morbidity arising from such sequelae. Tile potential for overdose to cause persisting morbidity is reviewed.
Affiliation :
Nal Drug Alcohol Res. Ctre, Univ. New South Wales, Sydney
Australie. Australia.
Australie. Australia.