Historique
Périodique
Gender differences in cocaine craving among non-treatment-seeking individuals with cocaine dependence
(Différences selon le sexe concernant le manque chez des usagers dépendants à la cocaïne ne cherchant pas à se soigner))
Auteur(s) :
ELMAN, I. ;
KARLSGODT, K. H. ;
GASTFRIEND, D. R.
Année
2001
Page(s) :
193-202
Langue(s) :
Anglais
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
American Journal of Drug and Alcohol Abuse, 2001, 27, (2), 193-202
Résumé :
The purpose of this pilot study was to evaluate potential gender differences in cocaine craving among non-treatment seekers with cocaine dependence. We examined 10 female and 11 male individuals matched by demographic characteristics and severity of drug use; we used a multidimensional questionnaire that assesses various aspects of craving: (a) current intensity, (b) projected intensity, (c) resistance to use cocaine, (d) responsiveness to drug-related conditioned stimuli, and (e) imagined likelihood of use if in a setting with access to drugs. Other instruments utilized were the Hamilton Rating Scale for Depression and Addiction Severity Index. Female subjects had higher total craving scores (p < .05), with post hoc tests showing more present desire to use cocaine and responsivity to drug-conditioned stimuli, along with lower scores on the desire not to use cocaine. In exploratory analyses, we found greater depressive symptomatology (p = .02) and severity of family/social problems (p = .02) in females than their males counterparts. These results suggest that gender may influence different aspects of cocaine craving. As estrogen is purported to modulate craving-related dopaminergic systems, further studies will be needed to confirm these observed gender differences and to investigate their possible mechanisms, particularly estrogen-dopamine interactions and their effect on craving and mood. (Author' s abstract)
Affiliation :
Addiction Services, Dept. Psychiatry, Massachusetts General Hosp., Harvard Medical Sch., 15 Parkmann st., WACC-812, Boston, MA 02114
Etats-Unis. United States.
Etats-Unis. United States.