Historique
Périodique
A putative sigma receptor antagonist NE-100 attenuates the discriminative stimulus effects of ketamine in rats
(Un éventuel antagoniste du récepteur sigma, le NE-100, diminue les effets d'un stimulus descriminatoire de la kétamine chez le rat.)
Auteur(s) :
NARITA, M. ;
YOSHIZAWA K. ;
AOKI, K. ;
TAKAGI M. ;
MIYATAKE M. ;
SUZUKI, T.
Année
2001
Page(s) :
373-376
Langue(s) :
Anglais
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PSY (Psychopathologie / Psychopathology)
Note générale :
Addiction Biology, 2001, 6, (4), 373-376
Résumé :
Ketamine, one of the dissociative anaesthetic agents, has been shown to produce psychotomimetic effects. It has been well documented that activation of sigma receptors is responsible for the pathogenesis of some psychiatric disorders. In the present study, the effects of NE-100, a putative sigma, receptor antagonist, was investigated in rats trained to discriminate between ketamine (5 mg/kg, i.p.) from saline under a fixed-ratio 10 food-reinforced procedure. Here we report for the first time that NE-100 (1 mg/kg) produced a shift to the right in the dose-response curve for ketamine's discriminative stimulus effects. These results suggest that the sigma receptor is, at least in part, involved in the discriminative stimulus effects of ketamine. (Author' s abstract)
Affiliation :
Dprt Toxicology, School of pharmacy, Hoshi Univ., 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501.
Japon. Japan.
Japon. Japan.