Historique
Périodique
Molecular neurobiology of addiction
(Neurobiologie moléculaire de l'addiction)
Auteur(s) :
NESTLER, E. J.
Année
2001
Page(s) :
201-217
Langue(s) :
Anglais
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PSY (Psychopathologie / Psychopathology)
Note générale :
American Journal on Addictions, 2001, 10, (3), 201-217
Résumé :
Addiction can be viewved as a form of drug-induced neural plasticity. One of the best established molecular mechanisms of addiction is the upregulation of the cAMP second messenger pathway, which occurs in many neuronal cell types in response to chronic administration of opiates or other dru gs of abuse. This upregulation and the resulting activation of the transcription factor CREB appear to mediate aspects of tolerance and dependence. In contrast, induction of another transcription factor, termed deltaFosB, exerts the opposite effect and may contribute to sensitized responses to drug exposure. Knowledge of these mechanisms could lead to more effective treatments for addictive disorders. (Author' s abstract)
Affiliation :
Dept Psychiat. Ctr Basic Neurosci., Univ. Texas Southwestern Med. Ctr, 5323 Harry Hines Blvd., Dallas, TX 75390-9070.
Etats-Unis. United States.
Etats-Unis. United States.