Historique
Périodique
Gradual dose taper following chronic buprenorphine
(Diminution graduelles des doses de buprénorphine après un traitement de maintenance.)
Auteur(s) :
BECKER, A. B. ;
STRAIN, E. C. ;
BIGELOW, G. E. ;
STITZER, M. L. ;
JOHNSON, R. E.
Année
2001
Page(s) :
111-121
Langue(s) :
Anglais
Domaine :
Autres substances / Other substances
Note générale :
American Journal on Addictions, 2001, 10, (2), 111-121
Résumé :
This paper describes the time course of withdrawal and relapse in opioid-dependent volunteers (n=8) who completed a gradual outpatient buprenorphine dose taper (28 days). Compliance with treatment was very high, as evidenced by clinic attendance (96-100%). Urinalysis showed that 6 of the 8 volunteers had relapsed to opiates by the end of the dose taper, even though reports of withdrawal were generally low. Relapse way have been triggered by a desire to re-experience the drug's positive subjective effects, cravinq, or low motivation to remain drug-free. A longer taper combined with an expanded range of treatments may improve prognosis. (Author' s abstract)
Affiliation :
Behavioral Pharmacology Research Unit, Johns Hopkins Bayview Medical Campus, 5510 Nathan Shock Dr., Baltimore, MD 21224.
Etats-Unis. United States.
Etats-Unis. United States.