Historique
Périodique
Ethanol increases plasma delta9-tetrahydrocannabinol (THC) levels and subjective effects after marihuana smoking in human volunteers
(L'éthanol augmente les taux plasmatiques de delta9-THC et les effets subjectifs de la marihuana fumée chez des sujets volontaires)
Auteur(s) :
LUKAS, S. E. ;
OROZCO, S.
Année
2001
Page(s) :
143-149
Langue(s) :
Anglais
Domaine :
Alcool / Alcohol ; Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
ALCOOL
;
CANNABIS
;
TETRAHYDROCANNABINOL
;
POLYCONSOMMATION
;
POTENTIALISATION
;
COMPORTEMENT
Note générale :
Drug and Alcohol Dependence, 2001, 64, (2), 143-149
Résumé :
Marihuana and alcohol are often used together, yet little is known about why they are combined. Male volunteers were assigned to one marihuana treatment group (placebo, low or moderate dose A9-tetrahydrocannabinpl (THC) and, on three separate study days, they also drank a different dose of ethanol (placebo, 0.35 or 0.7 g/kg). Plasma THC levels and changes in subjective mood states were recorded for 90 min after smoking. For many of the drug combinations, when subjects consumed ethanol they detected marihuana effects more quickly, reported more episodes of euphoria and had higher plasma THC levels than when they consumed placebo ethanol. These data suggest that ethanol may increase the absorption of THC resulting in an increase in the positive subjective mood effects of smoked marihuana and contributing to the popularity of this drug combination. Science Ireland Ltd. All rights reserved. (Author's abstract.)
Affiliation :
Pediatric Oncology, D363, Dana-Faber Cancer Inst., 44 Binney Str., Boston, MA 02115
Etats-Unis. United States.
Etats-Unis. United States.