Historique
Périodique
The effects of chronic morphine on behavior reinforced by several opioids or by cocaine in rhesus monkeys
(Effets de l'administration chronique de morphine sur le renforcement du comportement par les opiacés ou la cocaïne chez des singes rhésus)
Auteur(s) :
WINGER, G. ;
WOODS, J. H.
Année
2001
Page(s) :
181-189
Langue(s) :
Anglais
Domaine :
Autres substances / Other substances ; Drogues illicites / Illicit drugs
Thésaurus mots-clés
MORPHINE
;
OPIACES
;
COCAINE
;
TOLERANCE
;
AUTOADMINISTRATION
;
RENFORCEMENT
;
MODELE ANIMAL
Note générale :
Drug and Alcohol Dependence, 2001, 62, (3), 181-189
Résumé :
The reinforcing effects of intravenously delivered cocaine, alfentanil, morphine, heroin, nalbuphine, or buprenorphine were evaluated in four rhesus monkeys before, during, and after daily administration of 3.2 mg/kg morphine. Morphine was given 21 h prior to measures of the reinforcing effects of each of the drugs. No changes in the potency of cocaine or the high efficacy mu agonist alfentanil were detectable during the period of chronic morphine administration. Small (1/2-1) log unit decreases in the reinforcing potency of intermediate efficacy mu agonists morphine and heroin occurred during chronic morphine administration. Larger decreases in both the potency and effectiveness of low-efficacy mu agonists nalbuphine and buprenorphine developed during this time. These data suggest that the amount of tolerance that develops to the reinforcing effects of opioids depends on the efficacy of the drugs used to maintain responding. (Author's abstract.)
Affiliation :
Dept. Pharmacol., Univ. MI, 1501 W. Medical Ctr. Drive, Ann Arbor, MI 48109
Etats-Unis. United States.
Etats-Unis. United States.