Historique
Rapport
Within- and between-subject variability in the reinforcing and subjective effects of nitrous oxide in healthy volunteers
(Renforcement des effets subjectifs du protoxyde d'azote chez des volontaires sains : variabilité inter et intra individus)
Auteur(s) :
WALKER, D. J. ;
ZACNY, J. P.
Année
2001
Page(s) :
85-96
Langue(s) :
Anglais
Domaine :
Autres substances / Other substances
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
PROTOXYDE D'AZOTE
;
INHALANTS
;
CONDITIONNEMENT
;
POTENTIEL ADDICTIF
;
FACTEUR DE VULNERABILITE
Note générale :
Drug and Alcohol Dependence, 2001, 64, (1), 85-96
Résumé :
Within- and between-subject variability in the reinforcing and subjective effects of nitrous oxide (N2O) was studied across five sessions. Twelve volunteers with no history of drug dependence sampled 30% N2O and 100% oxygen for 10 min each, then chose nine times, once every 5 min, among N2O (e.g. "Agent A"), oxygen (e.g. "Agent B"), or "drug-free air." Choice varied across subjects but was stable within subjects. Quantitative differences in subjective effects occurred within and across subjects. Some subjective effects were correlated with choice and/or differed between subjects who were consistent choosers of N2O versus those who were not. However, drug liking and euphoria, two face-valid measures of abuse liability, were unrelated to choice. Thus, the present study found individual differences (i.e. between-subject variability) in subjective and reinforcing effects of N2O and, in terms of within-subject variability, suggested that subjective effects fluctuate across sessions to a relatively greater extent than do reinforcing effects. The varying degrees of correlation between N2O choice and its subjective effects emphasize the need for obtaining multiple measures when characterizing abuse liability of this drug. (Author's abstract.)
Affiliation :
Univ. Chicago, Dept. Anesthesia Critical Care 5841 S. Maryland Ave., MC 4028 Chicago, IL 60637
Etats-Unis. United States.
Etats-Unis. United States.