Historique
Périodique
Effects of cocaine prior to and during bupropion maintenance in cocaine-abusing volunteers
(Effets de la cocaïne avant et au cours d'un traitement de maintenance par le bupropion chez des volontaires dépendants de cocaïne)
Auteur(s) :
OLIVETO, A. ;
McCANCE-KATZ, E. F. ;
SINGHA, A. ;
PETRAKIS, I. ;
HAMEEDI, F. ;
KOSTEN, T. R.
Année
2001
Page(s) :
155-167
Langue(s) :
Anglais
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
COCAINE
;
BUPROPION
;
ANTIDEPRESSEURS
;
SEVRAGE
;
ESSAI THERAPEUTIQUE
;
EFFET SECONDAIRE
;
APPAREIL CARDIOVASCULAIRE
;
TRAITEMENT DE MAINTENANCE
Note générale :
Drug and Alcohol Dependence, 2001, 63, (2), 155-167
Résumé :
The effects of cocaine were examined prior to and during bupropion maintenance in nonopioid-dependent cocaine abusers. Prior to bupropion maintenance, subjects underwent an experimental session during which repeated cocaine doses (0, 50, 100 mg/70 kg) were administered intranasally. Then subjects were maintained on bupropion (150 and 300 mg per day) and underwent experimental sessions as before. Cocaine, regardless of bupropion, produced dose-related increases in several stimulant-like self-reports, performance and cardiovascular measures. Bupropion decreased POMS ratings of friendliness and vigor, regardless of cocaine dose. Bupropion enhanced and attenuated cocaine-induced increases in ratings on the LSD and BG subscales of the ARCI, respectively. These results suggest that bupropion does not alter the acute subjective or cardiovascular effects of cocaine in a robust manner. (Author's abstract.)
Affiliation :
VA Connecticut Healthcare System, Psychiatr. 116A-4, Building 36, 950 Campbell Ave., West Haven, CT
Etats-Unis. United States.
Etats-Unis. United States.