Historique
Périodique
Neuroadaptaciones en los sistemas glutamatérgico y dopaminérgico durante la abstinencia de la cocaina
(Neuroadaptations dans les systèmes glutamatergique et dopaminergique lors de l'abstinence à la cocaïne) ; (Neuroadaptations in glutamatergic and dopaminergic systems during cocaine withdrawal)
Auteur(s) :
CRESPO, J. A. ;
MARTIN, S. ;
AMBROSIO, E.
Année
2001
Page(s) :
7-16
Langue(s) :
Espagnol
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PSY (Psychopathologie / Psychopathology)
Thésaurus mots-clés
COCAINE
;
DOPAMINE
;
RECEPTEUR
;
RECHUTE
;
ABSTINENCE
;
AUTOADMINISTRATION
;
RENFORCEMENT
Note générale :
Adicciones, 2001, 13, (1), 7-16
Résumé :
There are different factors that could participate in relapse to drug addiction. These factors are characterized as exogenous and endogenous. It is clear that exogenous factors such as peer groups, poor socioeconomical level, etc., are relevant to induce relapse, in drug addiction. However, the role of endogenous factors such as disregulation of neurotransmitter systems, subject's personality, etc., are less understood. In this work we present data that suggest that, after extinction of cocaine self-administration in rats, there are neuroadaptative changes in dopaminergic and glutamatergic brain receptors in cerebral areas involved in cocaine reinforcing effects. These neuroadaptations are more permanent and long lasting in dopaminergic receptors compared to glutamatergic receptors. The results of this study suggest that specific neuroadaptative changes in glutamatergic and dopaminergic receptor systems might be involved in negative states of cocaine withdrawal and facilitate vulnerability to cocaine relapse. (Review's abstract.)
Affiliation :
Dept Psicol., Univ. Nac. Educ. Distancia (UNED), Ciudad Univ., 28040 Madrid
Espagne. Spain.
Espagne. Spain.