Historique
Périodique
The cannabinoid receptor gene (CNR1) is not affected in German intraveinous. drug users
(Le gène du récepteur des cannabinoïdes (CNR1) n'est pas affecté chez des usagers de drogues par voie intraveineuse en Allemagne.)
Auteur(s) :
HELLER, D. ;
SCHNEIDER, U. ;
SEIFERT, J. ;
CIMANDER, K. F. ;
STUHRMANN, M.
Année
2001
Page(s) :
183-187
Langue(s) :
Anglais
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PAT (Pathologie organique / Organic pathology)
Thésaurus mots-clés
CANNABINOIDES
;
RECEPTEUR
;
GENETIQUE
;
PATHOLOGIE
;
ETIOLOGIE
;
VOIE INTRAVEINEUSE
;
ETUDE TRANSVERSALE
Thésaurus géographique
ALLEMAGNE
Note générale :
Addiction Biology, 2001, 6, (2), 183-187
Résumé :
The aim of the study was to investigate a possible contribution of the cannabinoid receptor gene (CNR1) to the development of i.v. drug addiction. Allele and genotype frequencies of a previously associated flanking triplet repeat polymorphism were compared between patients and controls, and the whole coding region of the CNR1 gene of all patients were screened for presence of mutations. The study took place at the Addiction Treatment Unit of the Medical School Hannover, and two outpatients' departments in Hannover, Germany. Forty German unrelated opioid addicts (27 males and 13 females; mean age 37.9 years; range 16-53 years), took part, all of them satisfying ICD-10 and DSM-IV diagnostic criteria for opioid dependence and 81 age- and sex- matched controls (German blood donors). Measurements used were lengths of alleles, genotyping and single strand conformation polymorphism (SSCP) analysis. Neither the > 5 alleles of the extragenic triplet repeat (AAT) marker nor the alleles of an intragenic biallelic CNR1 polymorphism (1359G/A) were associated with i. v. drug use in our study group. In addition, we did not detect any sequence variation within the CNRI gene which could confer susceptibility to i.v. drug abuse. In contrast to previous investigations, we found no evidence for an involvement of the CNR1 gene in i.v. drug addiction. (Author' s abstract)
Affiliation :
Inst. Human Genetics, Med. School Hannover, Carl-Neuberg-Str. 1, D-30625 Hannover
Allemagne. Germany.
Allemagne. Germany.