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Influence of concomitant drugs on methadone elimination half-life in patients under a maintenance treatment
(Influence de l'usage concomittant de médicaments sur la demi-vie de la méthadone chez des patients en traitement de maintenance.)
Auteur(s) :
LUCAS, A. C. S. ;
BERMEJO, A. M. ;
TABERNERO, M. J. ;
FERNANDEZ, P. ;
CAMPORA, P.
Année
2001
Page(s) :
171-176
Langue(s) :
Anglais
Domaine :
Autres substances / Other substances
Thésaurus mots-clés
METHADONE
;
METABOLISME
;
MEDICAMENTS
;
INTERACTION CHIMIQUE
;
MESURES QUANTITATIVES
;
URINE
Note générale :
Addiction Biology, 2001, 6, (2), 171-176
Résumé :
Methadone elimination half-life was determined in 18 patients under maintenance treatments and found to range from 2.05 to 49.6 h. A study of potential correlations between this parameter and the presence of concomitant drugs, inhibitors or inducers of cytochrome P450, revealed an increase or decrease of methadone elimination half-life, respectively. Twenty-four-hour urinary excretion of methadone was determined in three patients, who were found to release 22.3-49.8% of the dose taken. The amount excreted varied with the chemical form (unaltered drug or its main metabolite) in the three cases. No statistically significant correlation was found between urine pH and the elimination half-life (p < 0.50). (Author' s abstract)
Affiliation :
Purificacion Fernandez, Inst. Legal Medicine, Forensic Toxicology Serv., Faculty Medicine, C/San Francisco, S/N, 15705 Santiago de Compostela
Espagne. Spain.
Espagne. Spain.