Historique
Périodique
Salivary cortisol during opiate dependence and withdrawal
(La sécrétion salivaire de cortisol lors du sevrage chez des personnes dépendant des opiacés.)
Auteur(s) :
BEARN, J. ;
BUNTWAL, N. ;
PAPADOPOULOS, A. ;
CHECKLEY, S.
Année
2001
Page(s) :
157-162
Langue(s) :
Anglais
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
OPIACES
;
DESINTOXICATION
;
CURE DE DESINTOXICATION
;
SYNDROME DE SEVRAGE
;
CORTICOIDES
;
SALIVE
;
MESURES QUANTITATIVES
Note générale :
Addiction Biology, 2001, 6, (2), 157-162
Résumé :
Seventeen inpatients (14 men, three women) with opiate dependence and polysubstance misuse participated in a longitudinal study of salivary cortisol secretion during and after lofexidine detoxification treatment. Both opiate withdrawal symptoms and salivary cortisol were measured every morning for up to 25 days. Results were compared with a control group of 10 normal volunteers. There was an 80% reduction in withdrawal symptom severity between the first 12 days and the subsequent 12 days of treatment. Salivary cortisol fell from a mean of 22.3nm/l over days 1-12 to 18.5nm/l during days 13-25, a reduction of 17%. Salivary cortisol concentration correlated significantly with withdrawal symptom severity. Salivary cortisol levels remained significantly higher than controls for the duration of the study. The study supports a role for hypothalamo-pituitary-adrenal (HPA) activation in opiate withdrawal. The contribution of persistant dysregulation of the HPA, found in this study, to the vulnerability for relapse after abstinence has been achieved, is discussed. (Author' s abstract)
Affiliation :
Wickham Park House, Bethlem Royal Hosp., Monks Orchard Road, Beckenham, Kent BR3 3BX
Royaume-Uni. United Kingdom.
Royaume-Uni. United Kingdom.