Historique
Périodique
Thrombocytopenia in HIV-infected drug users in the HAART era
(Thrombocytopénie chez des usagers de drogues à l'ère des traitements anti-viraux hautement actifs - HAART.)
Auteur(s) :
BURBANO X. ;
MIGUEZ M. J. ;
LECUSAY R. ;
RODRIGUEZ, A. ;
RUIZ, P. ;
MORALES, G. ;
CASTILLO, G. ;
BAUM, M. ;
SHOR-POSNER G.
Année
2001
Page(s) :
456-461
Langue(s) :
Anglais
ISBN :
0953-7104
Refs biblio. :
17
Domaine :
Drogues illicites / Illicit drugs
Discipline :
MAL (Maladies infectieuses / Infectious diseases)
Thésaurus mots-clés
VIH
;
TRAITEMENT
;
ANTIVIRAUX
;
THROMBOSE
;
SANG
;
EFFICACITE
;
ETUDE LONGITUDINALE
Note générale :
Platelets, 2001, 12, 456-461
Note de contenu :
graph.
Résumé :
ENGLISH :
The present case-control study compared 26 HIV+ drug users having persistent thrombocytopenia (TCP<150 000/mm3) with 54 available age, gender and HIV CDC classification matched controls with normal platelet counts. Participants were followed longitudinally over a 2-year period (1998-2000), and hematological alterations evaluated in relationship to antiretroviral treatment, drug use and nutritional (selenium) status. Demographic information and medical history, including antiretroviral treatment were obtained. Blood was drawn for complete cell blood count, T lymphocytes and viral load. Sixty-nine percent of the individuals with persistent TCP and 49% of the controls were receiving antiretrovirals. At baseline, no significant differences in CD4 existed between the two groups. Over time, CD4 cell count declined in the cases (P = 0.05) and a significantly higher proportion of the cases (38%) developed AIDS (CD4<200 cell/mm3), as compared to the controls (18%, P = 0.004). A high risk for development of thrombocytopenia was observed with specific drug use (heroin 2.96 times, P = 0.0007), selenium levels below 145 ug/l (6 times, P = 0.008), and abnormal liver enzyme (SGOT) levels (2 times, P = 0.002). Together, these results indicate a number of factors that may be sensitive predictors of thrombocytopenia, which, despite antiretroviral treatment, appears to be related to more rapid disease progression in drug users. (Editor' s abstract)
Affiliation :
France. France.