Historique
Périodique
Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons
(Une exposition unique à la cocaïne in vivo entraîne une potentialisation à long terme au niveau des neurones dopaminergiques.)
Auteur(s) :
UNGLESS, M. A. ;
WHISTLER J. L. ;
MALENKA, R. C. ;
BONCI A.
Année
2001
Page(s) :
583-587
Langue(s) :
Anglais
Refs biblio. :
30
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Nature, 2001, 411, 583-587
Note de contenu :
fig.
Résumé :
ENGLISH :
How do drugs of abuse modify neural circuitry and thereby lead to addictive behaviour? As for many forms of experience-dependent plasticity, modifications in glutamatergic synaptic transmission have been suggested to be particularly important. Evidence of such changes in response to in vivo administration of drugs of abuse is lacking, however. Here we show that a single in vivo exposure to cocaine induces long-term potentiation of AMPA (alpha-amino-3-hydroxy-5-methyl-isoxazole propionic acid)-receptor-mediated currents at excitatory synapses onto dopamine cells in the ventral tegmental area. Potentiation is still observed 5 but not 10 days after cocaine exposure and is blocked when an NMDA (N-methyl-D-aspartate) receptor antagonist is administered with cocaine. Furthermore, long-term potentiation at these synapses is occluded and long-term depression is enhanced by in vivo cocaine exposure. These results show that a prominent form of synaptic plasticity can be elicited by a single in vivo exposure to cocaine and therefore may be involved in the early stages of the development of drug addiction. (Author' s abstract)
Affiliation :
Ernest Gallo Clinic Res. Ctr., Dep Neurology, Univ. California, San Francisco, California 94110
Etats-Unis. United States.
Etats-Unis. United States.