Historique
Périodique
Learning about addiction from the genome
(Connaître l'addiction en étudiant le génome.)
Auteur(s) :
NESTLER, E. J. ;
LANDSMAN, D.
Année
2001
Page(s) :
834-835
Langue(s) :
Anglais
Refs biblio. :
15
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Nature, 2001, 409, 834-835
Note de contenu :
graph. ; tabl.
Résumé :
FRANÇAIS :
Cette étude soulève l'importance de connaître les gènes humains impliqués dans les mécanismes biologiques de l'addiction, mais souligne aussi la limite des recherches actuelles : la difficulté à identifier quelles parties des gènes sont actives parmi la multitude des protéines qui ont un rôle potentiel.
ENGLISH :
Drug addiction can be defined as the compulsive seeking and taking of a drug despite adverse consequences. Although addiction involves many psychological and social factors, it also represents a biological process: the effects of repeated drug exposure on a vulnerable brain. The sequencing of the human and other mammalian genomes will help us to understand the biology of addiction by enabling us to identify both genes that contribute to individual risk for addiction and those through which drugs cause addiction. We illustrate this potential impact by searching a draft sequence of the human genome for genes related to desensitization of receptors that mediate the actions of drugs of abuse on the nervous system. (Author' s abstract)
Cette étude soulève l'importance de connaître les gènes humains impliqués dans les mécanismes biologiques de l'addiction, mais souligne aussi la limite des recherches actuelles : la difficulté à identifier quelles parties des gènes sont actives parmi la multitude des protéines qui ont un rôle potentiel.
ENGLISH :
Drug addiction can be defined as the compulsive seeking and taking of a drug despite adverse consequences. Although addiction involves many psychological and social factors, it also represents a biological process: the effects of repeated drug exposure on a vulnerable brain. The sequencing of the human and other mammalian genomes will help us to understand the biology of addiction by enabling us to identify both genes that contribute to individual risk for addiction and those through which drugs cause addiction. We illustrate this potential impact by searching a draft sequence of the human genome for genes related to desensitization of receptors that mediate the actions of drugs of abuse on the nervous system. (Author' s abstract)
Affiliation :
Dept of Psychiatry, Univ. of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390-9070.
Etats-Unis. United States.
Etats-Unis. United States.