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Cocaine sensitization and craving: differing roles for dopamine and glutamate in the nucleus accumbens
(Sensibilisation due à la cocaïne et manque : des rôles différents pour la dopamine et le glutamate dans le noyau accumbens.)
Auteur(s) :
CORNISH, J. L. ;
KALIVAS, P. W.
Année
2001
Page(s) :
43-54
Langue(s) :
Anglais
Refs biblio. :
51
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
COCAINE
;
BIOSENSIBILISATION
;
MANQUE
;
RECHUTE
;
MECANISME D'ACTION
;
DOPAMINE
;
NEUROTRANSMETTEURS
;
COMPARAISON
Note générale :
Journal of Addictive Diseases, 2001, 20, (3), 43-54
Note de contenu :
fig.
Résumé :
ENGLISH :
The repeated administration of cocaine produces enduring neuroadaptations that are associated with enhanced behavioral responsiveness to cocaine administration and lead to cocaine addiction and the manifestation of paranoid psychosis. This review describes the effect of chronic cocaine administration on dopamine and glutamate transmission in the nucleus accumbens, and discusses the relevance of these changes in the initiation of drug craving and relapse to drug abuse. Recent findings suggest that glutamate transmission in the nucleus accumbens is a dominant precipitator of relapse to drug-seeking activity, whereas both dopamine and glutamate transmission are important for sustaining drug-taking behavior. (Editor' s abstract)
Affiliation :
Dep. Physiology and Neuroscience, Med. Univ. South Carolina, 167 Ashley Ave, Suite 607, P.O. Box 250577, Charleston, SC 29425, email: cornishj@musc.edu
Etats-Unis. United States.
Etats-Unis. United States.