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Signal transduction mechanisms and behavioral sensitization to stimulant drugs: an overview of cAMP and PLA2
(Les mécanismes du signal de transduction et la sensibilisation comportementale : le rôle de l'adénosine cyclique (cAMP) et de la phospholipase PLA2
Auteur(s) :
GELOWITZ D. L. ;
BERGER, S. P.
Année
2001
Page(s) :
33-42
Langue(s) :
Anglais
Refs biblio. :
61
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Journal of Addictive Diseases, 2001, 20, (3), 33-42
Note de contenu :
fig.
Résumé :
ENGLISH :
Behavioral sensitization refers to the progressive increase of behavioral responses to psychomotor stimulants, which provides a model for the intensification of drug craving and relapse alleged to underlie addiction in humans. Mechanisms related to sensitization may also contribute to schizophrenia and bipolar disorder. While the phenomenon has been observed for years, only recently have molecular or intracellular mechanisms associated with behavioral sensitization been studied. An overview of cAMP and PLA2 (intracellular, signal transduction mechanisms) relevant to behavioral sensitization will be presented. (Editor' s abstract)
Affiliation :
Yale Univ. School Medicine, Section Neurobiology, 333 Cedar Street, Room SHM B408, New Haven, CT 06510, email: douglas.gelowitz@yale.edu
Etats-Unis. United States.
Etats-Unis. United States.