Historique
Périodique
Toward a molecular understanding of psychostimulant actions using genetically engineered dopamine receptor knockout mice as model systems
(Vers une compréhension moléculaire des actions des psychostimulants en utilisant comme modèle des souris génétiquement rendues insensibles à la stimulation de certains sous-types de récepteurs dopaminergiques.)
Année
2001
Page(s) :
7-18
Langue(s) :
Anglais
Refs biblio. :
44
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
STIMULANTS
;
MECANISME D'ACTION
;
DOPAMINE
;
RECEPTEUR
;
MODELE ANIMAL
;
NEUROBIOLOGIE
Note générale :
Journal of Addictive Diseases, 2001, 20, (3), 7-18
Résumé :
ENGLISH :
A major focus in studying the progression and prevention of addictive diseases has been to understand the molecular and cellular mechanisms underlying drug addiction. The brain dopaminergic system plays a central role in reward and motivation and is thought to be the main neural substrate for the actions of abusive drugs. We have used the gene targeting technology to generate dopamine D1 and D3 receptor knockout mice and used these mice as model systems to gain a molecular understanding of acute effects of psychostimulants cocaine and amphetamine. The use of a combined approach involving behavioral, electro-physiological as well as molecular studies has allowed us to define initially the roles of dopamine D1 and D3 receptors in the acute effects of psychostimulants and will enable us to understand mechanisms underlying their chronic actions in the future. (Editor' s abstract)
Affiliation :
Dep. Cell Biology, Neurobiology and Anatomy, Univ. Cincinnati Coll. Medicine, 3125 Eden Ave, Cincinnati, OH 45267-0521, email: ming.xu@uc.edu
Etats-Unis. United States.
Etats-Unis. United States.