Historique
Périodique
Neuroimagen y alteraciones del funcionamiento cerebral, asociadas al consumo de cocaina
(Imagerie neuronale et altérations du fonctionnement cérébral en lien avec la consommation de cocaïne) ; (Imaging technics and structural disturbances of the brain functioning in relation with cocaine abuse)
Auteur(s) :
GUARDIA, J. ;
SEGURA, L. ;
GONZALVO B. ;
IGLESIAS, L. ;
RONCERO C.
Année
2001
Page(s) :
415-431
Langue(s) :
Espagnol
Refs biblio. :
65
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
ABUS
;
COCAINE
;
IMAGERIE MEDICALE
;
LESIONS CEREBRALES
;
NEUROBIOLOGIE
;
DOPAMINE
;
TROUBLES DE LA MEMOIRE
Note générale :
Adicciones, 2001, 13, (4), 415-431
Résumé :
ENGLISH :
Cocaine abuse can induce neuro-posychiatric impairment, like hypofrontality, that can be shown as clinical symptoms like behavioral desinhibition, emotional instability, impulsivity, depression, anhedonia, paranoid ideation and cognitive impairment. Structural neuroimage techniques can assess brain shrinking and other structural disturbances. Spectroscopic magnetic resonance has found some signs of neuronal injury and glial proliferation, predominantly in frontal lobes. Functional neuroimage techniques have found defects in blood brain perfusion, that can be persistent during some months, after detoxification, and that have been associated to the presence of cognitive impairment and other neuropsychological disturbances. Furthermore a reduction in doparninergic receptor D2 density has been found in the cerebral cortex and a decrease in the binding to the dopamine transporter, in basal ganglia and thalamus, might be related to a hypodopaminergic state of the brain, due to chronic cocaine abuse. Cognitive and mood symptoms, and behavioral disturbances shown by cocaine abusers, while in a recovery therapeutic program, can be related to brain organic disturbances, induced by cocaine, and can increase the early relapse risk. (Review's abstract.)
Affiliation :
Unidad Conductas Adictivas, Serv. Psiquiatr., Hosp. Santa Creu i San Paul, C/San Antonio Maria Claret, 167, 08025 Barcelona
Espagne. Spain.
Espagne. Spain.