Historique
Périodique
Implementation of a clinic policy of client-regulated methadone dosing
(Mise en oeuvre d'une politique clinique de régulation de la dose de méthadone par le patient)
Auteur(s) :
ROBLES, E. ;
MILLER, F. B. ;
GILMORE-THOMAS, K. K. ;
McMILLAN, D. E.
Année
2001
Page(s) :
225-230
Langue(s) :
Anglais
Refs biblio. :
28
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
METHADONE
;
MESURES QUANTITATIVES
;
COHORTE
;
TRAITEMENT DE MAINTENANCE
;
AUTOADMINISTRATION
Note générale :
Journal of Substance Abuse Treatment, 2001, 20, (3), 225-230
Note de contenu :
graph.
Résumé :
ENGLISH :
A six-month interval (baseline) during which methadone doses above 99 mg required individual approval by the clinic's physician was compared with the subsequent 16-month period in which a policy of patient-regulated methadone dosing with no preset upper limit was implemented. During the later phase, all patients were required to remain at each selected dose for a minimum of four days, and standard compliance-based take-home dosing procedures were followed. For patients in the study sample (n=57), the daily maximum methadone dose increased from 165 mg during baseline to 300 mg during the self-regulation period, while their average daily methadone dose increased from 76.84 mg to 80.04 mg (W=473, n=57, P=0.01). Monthly percent of opiate-positive urine specimens decreased significantly from 5.26% during baseline to 1.64% during the self-regulated dose period (W=169, n=57, p< 0.01), and use of other drugs remained unchanged. No patient failed to show possession of recalled take-home doses, and no instances of liquid methadone diversion were reported by law enforcement agencies in the area. (Editor's abstract.)
Affiliation :
Dept. Pharmacol. Toxicol., Substance Abuse Treatment Clinic, Univ. Arkansas Med. Sciences, 4301 West Markham st, Little Rock, AR 72205-7199. E-mail : RoblesSoteloElias@exchange.uams.edu
Etats-Unis. United States.
Etats-Unis. United States.