Historique
Périodique
Effect of opioid dependence pharmacotherapies on Zidovudine disposition
(Effet des traitements de la dépendance aux opioïdes sur l'efficacité de la Zidovudine.)
Auteur(s) :
McCANCE-KATZ, E. F. ;
RAINEY P. M. ;
FRIEDLAND G. ;
KOSTEN, T. R. ;
JATLOW P.
Année
2001
Page(s) :
296-307
Langue(s) :
Anglais
Refs biblio. :
29
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
LAAM
;
ANTIRETROVIRAUX
;
BUPRENORPHINE
;
NALTREXONE
;
INTERACTION CHIMIQUE
;
PHARMACOCINETIQUE
Note générale :
American Journal on Addictions, 2001, 10, (4), 296-307
Note de contenu :
graph. ; tabl.
Résumé :
ENGLISH :
Injection drug users are frequently infected with human immunodeficiency virus (HIV) and receive opioid dependence pharmacotherapies and Zidovudine (ZDV), the latter as a component of highly active antiretroviral therapy. We previously reported that methadone substantially increases ZDV concentrations. We now report on oral ZDV pharmacokinetics in 52 subjects receiving the opioid dependence pharmacotherapies l-alpha-acetylmethadol LAAM, buprenorphine, or naltrexone, and 17 non-opioid-treated controls. Relative to the area under the time-concentration curve (AUC) of ZDV in control subjects, no statistically significant differences in ZDV AUC were observed in participants treated with LAAM (p=.75), buprenorphine (p=.37), or naltrexone (p=.34). While methadone maintenance may result in ZDV toxicity and possibly require dose adjustments, other opioid pharmacotherapies should not produce ZDV toxicity. (Author' s abstract)
Affiliation :
Albert Einstein College of Medicine, Bronx, NY
Etats-Unis. United States.
Etats-Unis. United States.