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Adverse outcomes in a controlled trial of pergolide for cocaine dependence
(Questions sur les effets du pergolide dans le traitement de la dépendance à la cocaine : résultats d'un essai contrôlé.)
Auteur(s) :
MALCOLM, R. ;
HERRON J. ;
SUTHERLAND, S. E. ;
BRADY, K. T.
Année
2001
Page(s) :
81-92
Langue(s) :
Anglais
Refs biblio. :
27
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
COCAINE
;
TRAITEMENT
;
DOPAMINE
;
AGONISTE
;
EFFICACITE
;
OBSERVANCE DU TRAITEMENT
;
EFFET SECONDAIRE
Note générale :
Journal of Addictive Diseases, 2001, 20, (1), 81-92
Note de contenu :
tabl.
Résumé :
ENGLISH :
We conducted a double-blind, multiple dose comparison study of pergolide versus placebo for the treatment of cocaine dependence. In the present study, we examined patients who met criteria for cocaine dependence without comorbid alcohol dependence (N = 255). Study completion rates favored placebo (48.9%) over the low dose (33.3%) and high dose (21.5%) pergolide subjects (x2(2) = 14,17, p < 0.001). Treatment effectiveness scores (TES) were significantly higher for the placebo group (31.7) than the low dose (25.2) and high dose (14.2) pergolide groups (F2,252 = 6.21, p = 0.002). There were no significant differences in side effect profiles after first dose of pergolide or placebo, or at study termination. Results of this study suggest that pergolide was not efficacious in the treatment of cocaine dependence due to reduced study participation. Caution regarding the outpatient use of pergolide in similar populations is warranted. (Author' s abstract)
Affiliation :
Ctr Drug Alcohol Prog., Med. Univ. South Carolina, 67 President St., Charleston, SC 29425
Etats-Unis. United States.
Etats-Unis. United States.