Historique
Périodique
The use of Levo-Alpha-Acetylmethadol (LAAM) in Methadone patients who have not achieved heroin abstinence
(Prescription de LAAM à des patients en traitement de maintenance à la méthadone non abstinents de l'héroïne.)
Auteur(s) :
BORG L. ;
HO, A. ;
WELLS, A. ;
JOSEPH, H. ;
APPEL, P. ;
MOODY, D. ;
KREEK, M. J.
Année
2002
Page(s) :
13-22
Langue(s) :
Anglais
Refs biblio. :
20
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
LAAM
;
ABSTINENCE
;
HEROINE
;
EFFICACITE
;
TRAITEMENT DE MAINTENANCE
;
METHADONE
Note générale :
Journal of Addictive Diseases, 2002, 21, (3), 13-22
Note de contenu :
graph.
Résumé :
ENGLISH :
Levo-alpha-acetylmethadol (LAAM) pharmacotherapy was offered to twelve patients who continued illicit opioid abuse after >- eleven months in methadone maintenance treatment. After 6-8 weeks on LAAM, plasma concentrations of the norLAAM metabolite varied significantly by LAAM dosing day, plasma adrenocorticotropin (ACTH) concentrations were significantly increased compared to methadone, and two of the seven subjects remaining in LAAM treatment were free of illicit opioids and nonprescribed methadone. After one year, one of five remaining subjects was using illicit opioids, and three were using non-prescribed methadone. While subject acceptance of LAAM was high, subjects were not in a "steady-state", with evidence of ongoing illicit opioid abuse. (Author' s abstract)
Affiliation :
The Rockfeller Univ., The Laboratory of the Biology of Addictive Diseases (Box 171), 1230 York Avenue, New York, NY 10021
Etats-Unis. United States.
Etats-Unis. United States.