Historique
Périodique
Optimizing long-term response to methadone maintenance treatment: A 152-week follow-up using higher-dose methadone
(Améliorer la réponse à long terme au traitement de maintenance à la méthadone : un suivi de 152 semaines de patients recevant de la méthadone haut dosage.)
Auteur(s) :
MAXWELL, S. ;
SHINDERMAN M. S.
Année
2002
Page(s) :
1-12
Langue(s) :
Anglais
Refs biblio. :
22
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
METHADONE
;
TRAITEMENT DE MAINTENANCE
;
POSOLOGIE
;
EFFICACITE
;
RETENTION
;
ETUDE LONGITUDINALE
Note générale :
Journal of Addictive Diseases, 2002, 21, (3), 1-12
Note de contenu :
graph. ; tabl.
Résumé :
ENGLISH :
We report the clinical course over 152 weeks of 245 patients in methadone maintenance treatment: 144 high dose (HD) patients (>- 100 mg/d, mean 211 mg/d), and 101 control (C) patients (< 100 mg/d, mean 65 mg/d). After 152 weeks the mean methadone doses were 284.9 mg/d (range 13-1100 mg/d) and 94.0 mg/d (range 10-500 mg/d), respectively. Overall retention in treatment was 59% over the 152 weeks, with the HD group having significantly better retention (61.1% vs. 46.3%) and lower rates of positive urine toxicologies (16.0% vs. 36.6%). Mortality was statistically the same for the HD group (2/144, 1.4%) and the C group (2/101, 1.9%) over the 152-week period. We conclude that doses of methadone exceeding 100 mg/d are safe and effective in long-term maintenance treatment. We attribute the favorable outcomes we report to a model of treatment that emphasizes medication management in the treatment of opioid addiction. (Author' s abstract)
Affiliation :
Center for Addictive Problems, 609 North Wells Street, Chicago, IL 60610
Etats-Unis. United States.
Etats-Unis. United States.