Historique
Périodique
Nimodipine in opiate detoxification: a controlled trial
(La nimodipine dans la désintoxication des opiacés : un essai contrôlé.)
Auteur(s) :
JIMENEZ-LERMA, J. M. ;
LANDABASO M. ;
IRAURGI I. ;
CALLE R. ;
SANZ, J. ;
GUTIERREZ-FRAILE, M.
Année
2002
Page(s) :
819-824
Langue(s) :
Anglais
Refs biblio. :
33
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
OPIACES
;
DESINTOXICATION
;
CURE DE DESINTOXICATION
;
BETABLOQUANTS
;
EFFICACITE
Note générale :
Addiction, 2002, 97, (7), 819-824
Note de contenu :
fig. ; tabl.
Résumé :
FRANÇAIS :
La nimodipine, inhibiteur calcique, est testée comme traitement du syndrome de sevrage des opiacés dans trois groupes de patients : un groupe recevant de la nimodipine et du dextropropoxiphène (antagoniste opiacés), un groupe recevant du dextropropoxiphène et des benzodiazépines, et un groupe recevant un agent alpha-adrénergique et de la naltrexone. Le groupe recevant de la nimodipine a présenté moins de symtômes de sevrage et d'une intensité moindre que les deux autres groupes. Le sevrage a également été plus confortable et sans complication.
ENGLISH :
Objective. To evaluate the use of L-type calcium channel blockers (CaCB) in out-patient opiate detoxification. Design. Controlled trial with sequential allocation of patients to groups. Methods. Three groups of individuals subject to opiate detoxification were involved: (1) the experimental group (n = 30) received a course of nimodipine and dextropropoxiphen; (2) one control group (n = 20) was detoxified with a course of dextropropoxiphen and benzodiazepine: and (3) a second control group (n = 30) was treated with a standard course of (x-2-adrenergic agents and naltrexone. In all cases, the detoxification course was scheduled to last 7 days. Results. All the groups showed a significant opiate withdrawal syndrome (OWS) during detoxification (follow-up effect: A = 0.04; F6.52 = 201.89; P < 0.001), but from the first day the group treated with CaCB manifested fewer symptoms than the control groups (treatment effect: F2.57 = 97.99; P < 0,001). From the start, the intensity of the OWS was reduced by half in the CaCB group (M = 6.67) compared with that manifested by the two other groups (M = environ 13). The clinical impression of the evolution of the detoxification was that it was comfortable and free of complications (significant side-effects were not observed). Conclusions. The results of the study suggest that the use of calcium channel blockers (CaCB) may be an effective method in opiate detoxification. Full randomized trials are warranted. (Author' s abstract)
La nimodipine, inhibiteur calcique, est testée comme traitement du syndrome de sevrage des opiacés dans trois groupes de patients : un groupe recevant de la nimodipine et du dextropropoxiphène (antagoniste opiacés), un groupe recevant du dextropropoxiphène et des benzodiazépines, et un groupe recevant un agent alpha-adrénergique et de la naltrexone. Le groupe recevant de la nimodipine a présenté moins de symtômes de sevrage et d'une intensité moindre que les deux autres groupes. Le sevrage a également été plus confortable et sans complication.
ENGLISH :
Objective. To evaluate the use of L-type calcium channel blockers (CaCB) in out-patient opiate detoxification. Design. Controlled trial with sequential allocation of patients to groups. Methods. Three groups of individuals subject to opiate detoxification were involved: (1) the experimental group (n = 30) received a course of nimodipine and dextropropoxiphen; (2) one control group (n = 20) was detoxified with a course of dextropropoxiphen and benzodiazepine: and (3) a second control group (n = 30) was treated with a standard course of (x-2-adrenergic agents and naltrexone. In all cases, the detoxification course was scheduled to last 7 days. Results. All the groups showed a significant opiate withdrawal syndrome (OWS) during detoxification (follow-up effect: A = 0.04; F6.52 = 201.89; P < 0.001), but from the first day the group treated with CaCB manifested fewer symptoms than the control groups (treatment effect: F2.57 = 97.99; P < 0,001). From the start, the intensity of the OWS was reduced by half in the CaCB group (M = 6.67) compared with that manifested by the two other groups (M = environ 13). The clinical impression of the evolution of the detoxification was that it was comfortable and free of complications (significant side-effects were not observed). Conclusions. The results of the study suggest that the use of calcium channel blockers (CaCB) may be an effective method in opiate detoxification. Full randomized trials are warranted. (Author' s abstract)
Affiliation :
Ctro Tratamiento Toxicomanias de Alava, C/Elvira Zalueta 4, 01007 Vitoria-Gasteiz
Espagne. Spain.
Espagne. Spain.