Historique
Périodique
An increase in overdose mortality during the first 2 weeks after entering or re-entering methadone treatment in Amsterdam
(Augmentation de la mortalité par overdose dans les deux premières semaines consécutives à l'admission ou à la ré-admission en traitement de maintenance sous méthadone à Amsterdam)
Auteur(s) :
BUSTER, M. C. A. ;
VAN BRUSSEL, G. H. A. ;
VAN DEN BRINK, W.
Année
2002
Page(s) :
993-1001
Langue(s) :
Anglais
Refs biblio. :
30
Domaine :
Drogues illicites / Illicit drugs
Discipline :
EPI (Epidémiologie / Epidemiology)
Thésaurus mots-clés
HEROINE
;
METHADONE
;
TRAITEMENT DE MAINTENANCE
;
ADMISSION
;
SURDOSE
;
MORTALITE
;
PREVALENCE
Thésaurus géographique
PAYS-BAS
Note générale :
Addiction, 2002, 97, (8), 993-1001
Note de contenu :
graph. ; tabl.
Résumé :
ENGLISH :
Aims: It has been suggested that starting and temporarily discontinuing methadone treatment is related to an increased risk in overdose mortality. This study describes the incidence of overdose mortality in relation to time after (re)entering or leaving treatment. Design: A dynamic cohort of 5200 Amsterdam methadone clients was observed during treatment and (a maximum of 1 year) after treatment. Findings: Between 1986 and 1998, 29 729 person-years (py) and 68 overdose deaths were recorded, leading to an overdose mortality rate of 2.3/1000 py (2.2 during and 2.4 after treatment). A modest increase was observed during the first 2 weeks after (re)entering treatment; 6.0/1000py (rate ratio: 2.9; 95% confidence interval 1.4; 5.8). Directly after leaving treatment no increase was observed. Conclusions: Inhaling heroin, common among Amsterdam heroin users, is thought to account for low OD mortality rates both during and after treatment. Accumulation of methadone, inadequate assessment of tolerance of known clients re-entering treatment and concurrent periods of stress or extreme heroin use when entering treatment are mentioned as possible explanations of the increased risk within the first 2 weeks. An Australian study reported a much higher increase. The modest increase in Amsterdam is explained by low background risk of overdose mortality, low starting dosage and the low threshold to treatment. (Author' s abstract)
Affiliation :
Municipal Health Service, Amsterdam Department of Epidemiology, Documentation and Health Promotion, PO Box 2200, 1000CE Amsterdam
Pays-Bas. Netherlands.
Pays-Bas. Netherlands.