Historique
Périodique
Maternal drug use is a preeminent risk factor for mother-to-child Hepatitis C virus transmission: results from a multicenter study of 1372 mother-infant pairs
(L'usage de drogues pendant la grossesse est un facteur de risque prééminent de la transmission mère-enfant du virus de l'hépatite C : résultats d'une étude multi-sites de 1372 couples mère-enfant.)
Auteur(s) :
RESTI M. ;
AZZARI, C. ;
GALLI L. ;
ZUIN, G. ;
GIACCHINO R. ;
BORTOLOTTI F. ;
MARCELLINI, M. ;
MORIONDO M. ;
DE MARTINO, M. ;
VIERUCCI A.
Année
2002
Page(s) :
567-572
Langue(s) :
Anglais
ISBN :
0022-1899
Refs biblio. :
29
Domaine :
Drogues illicites / Illicit drugs
Discipline :
MAL (Maladies infectieuses / Infectious diseases)
Thésaurus mots-clés
ETUDE PROSPECTIVE
;
VIRUS
;
HEPATITE
;
CONTAMINATION
;
MERE
;
GROSSESSE
;
ENFANT
;
FACTEUR DE RISQUE
;
CONSOMMATION
Note générale :
Journal of Infectious Diseases, 2002, 185, 567-572
Note de contenu :
tabl.
Résumé :
ENGLISH :
This prospective multicenter study evaluated separately the significance of maternal injection drug use (IDU) and human immunodeficiency virus type 1 (HIV-1) coinfection in vertical transmission of hepatitis C virus (HCV). In all, 1372 consecutive, unselected HCV antibody-positive mothers and their infants were studied. Maternal HIV- I coinfection (crude odds ratios [OR], 1.4 1; 95% confidence interval [CI], 1.16-1.66; P = .007) and IDU (OR, 1.58; 95% CI, 1.37-1.78; P < .00001) were linked to mother-to-child HCV transmission in unadjusted analysis when all anti-HCV-positive mothers were evaluated. When only HCV RNA-positive mothers were evaluated,maternal IDU, but not maternal HIV-1 coinfection, was significantly associated with mother- to-child HCV transmission. Multivariable analysis confirmed the link between maternal IDU and HCV transmission (adjusted OR [AOR], 1.51; 95% CI, 1.19-1,92; P = .0006), but no association was found with HIV-1 coinfection (AOR, 0.98; 95%CI, 0.73-1.33;P = .93).IDU, but not HIV-l co- infection, seems to be a preeminent risk factor for vertical HCV transmission. (Editor' s abstract)
Affiliation :
Univ. Florence, Pediatric Hosp. A. Meyer, Pediatric Clinic III, Via Luca Giordano 13, 50132, Florence, Email : m.resti@ao-meyer.toscana.it
Italie. Italy.
Italie. Italy.