Historique
Périodique
Isradipine enhancement of cerebral blood flow in abstinent cocaine abusers with and without chronic perfusion deficits
(Augmentation du flot cérébral sanguin par l'isradipine chez des cocaïnomanes abstinents présentant ou ne présentant pas un déficit chronique de perfusion.)
Auteur(s) :
GOTTSCHALK, P. C. H. ;
KOSTEN, T. R.
Année
2002
Page(s) :
200-208
Langue(s) :
Anglais
Refs biblio. :
25
Domaine :
Drogues illicites
Discipline :
PAT (Pathologie organique / Organic pathology)
Thésaurus mots-clés
COCAINE
;
PATHOLOGIE ORGANIQUE
;
APPAREIL CARDIOVASCULAIRE
;
BETABLOQUANTS
;
ETUDE TRANSVERSALE
Note générale :
American Journal on Addictions, 2002, 11, (3), 200-208, tabl.
Résumé :
Nine cocaine abusers with cerebral blood flow (CBF) deficits (hypo-perfused areas) on HMPAO SPECT scans were compared to six without these deficits after six doses of isradipine (5 mg TID). When comparing the scan before isradipine to that after using SPM analysis, the ratio of hypo- to hyper-fusion showed a 16% increase in the maximum Z scores and 30% fewer areas of hypo-perfusion among those cocaine abusers with deficits. These deficits may represent segmental cerebral vasospasm that was reversed by this vasodilating agent in cocaine abusers with areas of hypo-perfusion (deficits) as baseline. (Author' s abstract)
Affiliation :
VA Connecticut Healthcare System, Dep. Psychiatry 151D, 950 Campbell Ave., Building 35, West Haven, CT 06516
Etats-Unis. United States.
Etats-Unis. United States.