Historique
Périodique
Sex differences in the effects of baclofen on the acquisition of intravenous cocaine self-administration in rats
(Effets différenciés en fonction du sexe du baclofen sur l'autoadministration intraveineuse de cocaïne chez le rat)
Auteur(s) :
CAMPBELL, U. C. ;
MORGAN, A. D. ;
CARROLL, M. E.
Année
2002
Page(s) :
61-69
Langue(s) :
Anglais
Refs biblio. :
64
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
COCAINE
;
AGONISTE
;
AUTOADMINISTRATION
;
RENFORCEMENT
;
SEXE FEMININ
;
SEXE MASCULIN
;
COMPARAISON
;
MODELE ANIMAL
Note générale :
Drug and Alcohol Dependence, 2002, 66, (1), 61-69
Note de contenu :
graph.
Résumé :
ENGLISH :
Baclofen, a GABAb agonist, decreases both the maintenance and reinstatement of i.v. cocaine-reinforced responding in rats. In the present experiment the effects of baclofen were extended to a comparison of male and female rats during the acquisition of i.v. cocaine self-administration. Four groups of rats were trained to self-administer i.v. cocaine (0.2 mg/kg) under a fixed-ratio 1 (FR 1) schedule using an autoshaping procedure. The criterion for acquisition was a 5-day period during which a mean of 100 cocaine infusions were administered. Rats were given 30 days to reach this criterion. Male and female groups (n = 10-13) were pretreated with i.p. injections of baclofen (2.5 mg/kg) or vehicle 30-min prior to the sessions. A subset of rats (N = 5) that did not acquire cocaine self-administration continued to be exposed to the acquisition procedure after baclofen treatment ended. Pretreatment with baclofen decreased both the rate of acquisition of cocaine self-administration and the percentage of rats meeting the acquisition criterion to a greater extent in females than in males. Female rats that did not meet the acquisition criterion with baclofen treatment, acquired within a few days after treatment ended, The findings confirm previous reports of enhanced acquisition of cocaine self-administration in females versus males, and they indicate that baclofen suppressed the acquisition of cocaine self-administration significantly more in females than in males. (Author's abstract.)
Affiliation :
Dept. Psychiatr., Univ. Minnesota Med. Sch., Box 392 UMHC, Minneapolis MN 55455
Etats-Unis. United States.
Etats-Unis. United States.