Historique
Périodique
Association of a CB1 Cannabinoid Receptor Gene (CNR1) polymorphism with severe alcohol dependence
(Relation entre un polymorphisme du gène récepteur de cannabinoïde CB1 (CNR1) et une dépendance grave à l'alcool)
Auteur(s) :
SCHMIDT, L. G. ;
SAMOCHOWIEC J. ;
FINCKH, U. ;
FISZER-PIOSIK E. ;
HORODNICKI J. ;
WENDEL, B. ;
ROMMELSPACHER, H. ;
HOEHE M. R.
Année
2002
Page(s) :
221-224
Langue(s) :
Anglais
Refs biblio. :
21
Domaine :
Alcool / Alcohol
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
ALCOOL
;
CANNABINOIDES
;
RECEPTEUR
;
DEPENDANCE
;
GENETIQUE
;
FACTEUR DE VULNERABILITE
;
SYNDROME DE SEVRAGE ALCOOLIQUE
Note générale :
Drug and Alcohol Dependence, 2002, 65, (3), 221-224
Note de contenu :
tabl.
Résumé :
ENGLISH :
Due to the involvement of the endogenous cannabinoid system in brain reward mechanisms a silent polymorphism (1359G/A; Thr453Thr) in the single coding exon of the CB1 human cannabinoid receptor gene (CNRI) was analysed in 121 severely affected Caucasian alcoholics and 136 most likely non-alcoholic controls. The observed frequency of the A allele was 31.2% for controls and 42.1 % for alcoholics with severe withdrawal syndromes (P = 0.0 I 0). Post-hoc exploration indicated that this allelic association resulted from an excess of the homozygous A/A genotype in patients with a history of alcohol delirium (P = 0.031, DF 2), suggesting an increased risk of delirium (OR = 2.45, 95% CI 1.14-5.25). This finding suggests that the homozygous genotype CNRI 1359A/A confers vulnerability to alcohol withdrawal delirium. (Author's abstract.)
Affiliation :
Dept Psychiatr., Univ. Mainz, Untere Zahlbacher Str. 8, 55131 Mainz
Allemagne. Germany.
Allemagne. Germany.