Historique
Périodique
Gamma-hydroxybutyric acid: patterns of use, effects and withdrawal
(L'acide gammahydroxybutyrique : type d'usage, effets et sevrage.)
Auteur(s) :
MIOTTO, K. ;
DARAKJIAN J. ;
BASCH, J. ;
MURRAY, S. ;
ZOGG, J. ;
RAWSON, R.
Année
2002
Page(s) :
232-241
Langue(s) :
Anglais
Refs biblio. :
43
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
GHB
;
EFFET SECONDAIRE
;
PATHOLOGIE ORGANIQUE
;
TOXICITE
;
TOLERANCE
;
SYNDROME DE SEVRAGE
;
TYPE D'USAGE
Note générale :
American Journal on Addictions, 2002, 10, (3), 232-241
Note de contenu :
tabl.
Résumé :
ENGLISH :
Gamma-hydroxybutyric acid (GHB) is gaining popularity as a drug of abuse. Reports of toxicity and lethality associated with GHB use have increased. This survey study was designed to identify patterns of GHB use, its effects, and withdrawal syndrome. A survey inquiring about the effects of GHB was administered to 42 users. The results showed that GHB was used to increased feelings of euphoria, relaxation, and sexuality. Adverse effects occurred more frequently in daily users and polydrug users than in occasional GHB users. Loss of consciousness was reported by 66%, overdose by 28%, and amnesia by 13% of participants during GHB use and by 45% after GHB use. Three daily users developed a withdrawal syndrome that presented with anxiety, agitation, tremor, and delirium. Participants described GHB intoxication as having similarities to sedative-hypnotic or alcohol intoxication. Regular use has been shown to produce tolerance and dependence. Participants dependent on GHB reported using multiple daily doses around the clock. High frequency users appeared at the greatest risk for developing withdrawal delirium and psychosis after abrupt discontinuation of GHB use. (Author' s abstract)
Affiliation :
UCLA Dept Psychiat. Biobehav. Sci., 760 Westwood Plaza, Los Angeles, CA 90024. E-mail: kmiotto@mednet.ucla.edu
Etats-Unis. United States.
Etats-Unis. United States.