Historique
Périodique
Ketamine impairs multiple cognitive domains in rhesus monkeys
(Perturbations multiples des fonctions cognitives par la kétamine chez le singe rhésus)
Auteur(s) :
TAFFE M. A. ;
DAVIS, S. A. ;
GUTIERREZ, T. ;
GOLD, L. H.
Année
2002
Page(s) :
175-187
Langue(s) :
Anglais
Refs biblio. :
61
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Note générale :
Drug and Alcohol Dependence, 2002, 68, (2), 175-187
Note de contenu :
graph. ; tabl.
Résumé :
ENGLISH :
Available evidence suggests that recreational use and abuse of the dissociative anaesthetic ketamine is increasing. Characterization of the cognitive risks of ketamine exposure contributes substantially to understanding this growing public health threat. Although prior human studies demonstrate that ketamine impairs a range of cognitive skills, investigation in nonhuman models permits more precise exploration of neurochemical mechanisms which may underlie detrimental behavioral effects. Adult male rhesus monkeys (N = 7) were trained on a neuropsychological battery including tests of memory (delayed match-to-sample, DMS; self-ordered spatial search, SOSS), reaction time (RT), reinforcer efficacy and sustained attention (progressive ratio, PR) and fine motor coordination (bimanual motor skill, BMS). Battery performance was then serially challenged with acute doses of ketamine (0.3, 1.0, 1.78 mg/kg IM). Ketamine impaired DMS and SOSS in a dose x difficulty dependent manner with the most difficult task conditions disrupted at the 1.0 and 1.78 mg/kg doses. Thus, both visual recognition memory and working memory indices were affected. Ketamine also slowed RT and BMS performance and interfered with PR performance at the 1.78 mg/kg dose. Overall the present findings confirm that ketamine interferes with multiple aspects of cognition at subanesthetic doses in monkeys. (Review's abstract.)
Affiliation :
Dept. Neuropharmacol., Scripps Res. Inst., 10550 North Torrey Pines Rd, La Jolla, CA 92307
Etats-Unis. United States.
Etats-Unis. United States.