Historique
Périodique
Behavioral psychopharmacology of MDMA and MDMA-like drugs : a review of human and animal studies
(Eléments de psychopharmacologie concernant les effets du MDMA et de drogues similaires sur les comportements : examen des études portant sur les hommes ou les animaux)
Auteur(s) :
MARTINEZ-PRICE, D. L. ;
KREBS-THOMSON, K. ;
GEYER, M. A.
Année
2002
Page(s) :
43-67
Langue(s) :
Anglais
Refs biblio. :
100
Domaine :
Drogues illicites / Illicit drugs
Discipline :
PRO (Produits, mode d'action, méthode de dépistage / Substances, action mode, screening methods)
Thésaurus mots-clés
MECANISME D'ACTION
;
MDMA-ECSTASY
;
USAGE THERAPEUTIQUE
;
NEUROBIOLOGIE
;
MODELE ANIMAL
;
COMPORTEMENT
;
INHIBITION
;
TOXICITE
;
PHARMACOLOGIE
;
DROGUES DE SYNTHESE
Note générale :
Addiction Research, 2002, 10, (1), 43-67
Note de contenu :
Ill.
Résumé :
ENGLISH :
Since being classified as a Schedule I controlled substance, MDMA (3,4-methylene- dioxy-N-methylamphetamine; "ecstasy") has been the subject of controversy regarding its potential therapeutic usage, increased use by young people in the "Rave" culture, and issues of potential neurotoxicity. This review article summarizes much of the animal and human studies of the general behavioral effects of MDMA and MDMA-like drugs, as well as studies using specific locomotor activity and startle/prepulse inhibition paradigms. MDMA and related serotonergic drugs produce a unique beha- vioral profile in both humans and animals. The precise sites of action and mechanisms for these behavioral effects are still being studied. Carefully conducted studies of MDMA and related compounds in animal and human subjects will provide invaluable information that can be used to elucidate mechanisms underlying drug abuse, cognition, arousal, and motor activity, as well as mechanisms of neurotoxicity and the possible therapeutic value of MDMA. (Author's abstract)
Affiliation :
mgeyerucsd.edu
Etats-Unis. United States.
Etats-Unis. United States.