Historique
Périodique
Prison based detoxification for opioid dependence: a randomised double blind controlled trial of lofexidine and methadone
(Sevrage d'opiacés en prison : utilisation de la méthadone ou de la lofexidine dans un essai contrôlé en double-aveugle)
Auteur(s) :
HOWELLS C. ;
ALLEN, S. ;
GUPTA, J. ;
STILLWELL, G. ;
MARSDEN, J. ;
FARRELL, M.
Année
2002
Page(s) :
169-176
Langue(s) :
Anglais
Refs biblio. :
24
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
OPIACES
;
METHADONE
;
AGONISTE
;
SEVRAGE
;
COMPARAISON
;
ESSAI THERAPEUTIQUE
;
PRISON
Note générale :
Drug and Alcohol Dependence, 2002, 67, (2), 169-176
Note de contenu :
tabl.
Résumé :
ENGLISH :
This paper reports results from the first controlled trial of opioid withdrawal treatment in the UK using lofexidine in a prison setting. Seventy-four opioid dependent male inmates at a Southern England prison were randomised to receive either methadone (the standard prison treatment) or lofexidine using a randomised double-blind design. No significant statistical difference between the treatment groups was found in relation to the primary variable of severity of withdrawal symptoms (effect size = 0.12). No discernible difference was found in the sitting blood pressure or heart rate of the two groups during the trial. These results provide support for the use of lofexidine for the management of opioid detoxification in the prison setting. (Review's abstract.)
Affiliation :
Natl Addict. Ctr., Inst. Psychiatr., 4 Winsdor Walk, SE5 8AF, London
Etats-Unis. United States.
Etats-Unis. United States.