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Heroin detoxification with buprenorphine on an inpatient psychiatric unit
(La buprénorphine dans la désintoxication à l'héroïne chez des patients hospitalisés dans une unité psychiatrique)
Auteur(s) :
DIPAULA B. A. ;
SCHWARTZ, R. ;
MONTOYA, I. D. ;
BARRETT, D. ;
TANG, C.
Année
2002
Page(s) :
163-169
Langue(s) :
Anglais
Refs biblio. :
21
Domaine :
Drogues illicites / Illicit drugs
Thésaurus géographique
ETATS-UNIS
Thésaurus mots-clés
HEROINE
;
BUPRENORPHINE
;
COMORBIDITE
;
HOPITAL PSYCHIATRIQUE
;
EFFICACITE
Note générale :
Journal of Substance Abuse Treatment, 2002, 23, (3), 163-169
Note de contenu :
tabl.
Résumé :
ENGLISH :
The purpose of this open-label, uncontrolled study was to evaluate the feasibility of administering off-label buprenorphine in combination with ancillary medications for inpatient short-term detoxification of heroin-dependent patients at a psychiatric facility. A sample of 20 heroin-dependent patients admitted to an urban psychiatric hospital was administered buprenorphine 6, 4, and 2 mg/day during the first, second, and third day of detoxification, respectively, and then observed during the fourth and fifth day. Eighty-five percent of the subjects abused other substances, 75% reported cocaine abuse/dependence, 75°,% had comorbid mood disorders. All subjects completed the medication phase of the study. No clinically significant adverse events were reported. There was a significant decrease in the Clinical Investigation Narcotic Assessment (CINA) total score between baseline and days 2 through 5. The results suggest that buprenorphine is well tolerated and may be beneficial for medically supervised short-term withdrawal from heroin for hospitalized psychiatric patients. (Editor's abstract.)
Affiliation :
Walter P. Carter Ctr, Dept. Pharmacy Services, 630 W. Fayette st, Baltimore, MD 21201. E-mail : bdipaula@rx.umaryland.edu
Etats-Unis. United States.
Etats-Unis. United States.