Historique
Périodique
History and current status of opioid maintenance treatments: blending conference session
(Historique et état actuel du traitement de maintenance des opiacés : unir les séances de l'Assemblée)
Auteur(s) :
KREEK, M. J. ;
VOCCI, F. J.
Année
2002
Page(s) :
93-105
Langue(s) :
Anglais
Refs biblio. :
110
Domaine :
Drogues illicites / Illicit drugs
Thésaurus mots-clés
OPIACES
;
TRAITEMENT DE MAINTENANCE
;
BUPRENORPHINE
;
METHADONE
;
EFFICACITE
;
REGLEMENTATION
Thésaurus géographique
ETATS-UNIS
Note générale :
Journal of Substance Abuse Treatment, 2002, 23, (2), 93-105
Résumé :
ENGLISH :
Opiate addiction is a chronic, relapsing disorder. Left untreated, high morbidity and mortality rates are seen. Pharmacotherapies for this disorder using mu opiate agonists (methadone and levomethadyl acetate) and partial agonists have been developed in the last 40 years. Agonist pharmacotherapy with oral methadone for the treatment of opiate dependence was developed in clinical pharmacology studies at Rockefeller University by Dole, Nyswander, and Kreek. Further studies by this laboratory and others established that moderate to high dose treatment with methadone (80-120 mg) reduced or eliminated opiate use in outpatient settings with consequent reductions in morbidity and up to 4-fold reductions in mortality. Levomethadyl acetate (LAAM), a congener of methadone, is biotransformed to active metabolites responsible for its longer duration of action. The Federal Regulations regarding the dispensation of methadone and LAAM have recently been revised to facilitate the treatment of patients under a "medical maintenance" model. Future regulatory reform will likely involve the establishment of rules for "office based opioid treatment." (Editor's abstract.)
Affiliation :
Laboratory Biology Addictive Diseases, Rockefeller Univ. Hosp, New York, NY 10021. E-mail : fv6k@nih.gov
Etats-Unis. United States.
Etats-Unis. United States.